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鉴定和表征欧洲蜜蜂（Apis mellifera L.）中的 Egr 直系同源物作为神经即刻早期基因。

Identification and characterization of an Egr ortholog as a neural immediate early gene in the European honeybee (Apis mellifera L.).

机构信息

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

FEBS Lett. 2013 Oct 1;587(19):3224-30. doi: 10.1016/j.febslet.2013.08.014. Epub 2013 Aug 28.

DOI:10.1016/j.febslet.2013.08.014
PMID:23994532
Abstract

To date, there are only few reports of immediate early genes (IEGs) available in insects. Aiming at identifying a conserved IEG in insects, we characterized an Egr homolog of the honeybee (AmEgr: Apis mellifera Egr). AmEgr was transiently induced in whole worker brains after seizure induction. In situ hybridization for AmEgr indicated that neural activity of a certain mushroom body (a higher brain center) neuron subtype, which is the same as that we previously identified using another non-coding IEG, termed kakusei, is more enhanced in forager brains. These findings suggest that Egr can be utilized as an IEG in insects.

摘要

迄今为止，昆虫中仅有少数即时早期基因（IEGs）的报道。为了鉴定昆虫中的保守 IEG，我们对蜜蜂的 Egr 同源物（AmEgr：Apis mellifera Egr）进行了特征描述。AmEgr 在全身工蜂大脑中被短暂诱导，以响应癫痫诱导。AmEgr 的原位杂交表明，某种蘑菇体（高等脑中枢）神经元亚型的神经活动得到了增强，而这种神经元亚型与我们之前使用另一种称为 kakusei 的非编码 IEG 所鉴定的神经元亚型相同，在觅食者大脑中更为增强。这些发现表明 Egr 可以在昆虫中用作 IEG。

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