Singh Asem Surindro, Takhellambam Machathoibi Chanu, Cappelletti Pamela, Feligioni Marco
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.
Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
PLoS One. 2020 May 6;15(5):e0222256. doi: 10.1371/journal.pone.0222256. eCollection 2020.
kakusei is a non-coding RNA that is overexpressed in foraging bee brain. This study describes a possible role of the IEG kakusei during the daily foraging of honey bees. kakusei was found to be transiently upregulated within two hours during rewarded foraging. Interestingly, during unrewarded foraging the gene was also found to be up-regulated, but immediately lowered when food was not rewarded. Moreover, the kakusei overexpression was diminished within a very short time when the time schedule of feeding was changed. This indicates the potential role of kakusei on the motivation of learned reward foraging. These results provide evidence for a dynamic role of kakusei during for aging of bees, and eventually its possible involvement in learning and memory. Thus the kakusei gene could be used as search tool in finding distinct molecular pathways that mediate diverse behavioral components of foraging.
觉醒是一种在觅食蜜蜂大脑中过度表达的非编码RNA。本研究描述了即刻早期基因觉醒在蜜蜂日常觅食过程中的可能作用。研究发现，在有奖励的觅食过程中，觉醒在两小时内会短暂上调。有趣的是，在无奖励的觅食过程中，该基因也被发现上调，但当没有食物奖励时会立即下降。此外，当喂食时间安排改变时，觉醒的过度表达在很短的时间内就会减弱。这表明觉醒对学习性奖励觅食动机的潜在作用。这些结果为觉醒在蜜蜂觅食过程中的动态作用提供了证据，并最终证明其可能参与学习和记忆。因此，觉醒基因可作为一种搜索工具，用于寻找介导觅食行为不同组成部分的独特分子途径。
