Brain-Behaviour Research Group, University of New England, Armidale, New South Wales 2351, Australia.
Behav Brain Res. 2013 Nov 1;256:368-76. doi: 10.1016/j.bbr.2013.08.030. Epub 2013 Aug 28.
Although often considered as a mental disorder, depression is best described as a behavioral-neurobiological phenomenon. In addition, although usually reported as a unitary diagnosis, major depressive episode is composed of a range of different symptoms that can occur in nearly 1500 possible combinations to fulfill the required diagnostic criterion. To investigate and describe the underlying behavioral and neurobiological substrates of these symptoms, they were clustered into "clinical content" subtypes of depression according to their predominant common behavioral characteristics. These subtypes were then found to possess different neurobiological pathways that argue for different treatment approaches.
虽然抑郁症常被认为是一种精神障碍，但最好将其描述为一种行为-神经生物学现象。此外，虽然通常报告为单一诊断，但重度抑郁发作由一系列不同的症状组成，这些症状可以以近 1500 种不同的组合出现，以满足所需的诊断标准。为了研究和描述这些症状的潜在行为和神经生物学基础，根据其主要的共同行为特征，将它们聚类为抑郁症的“临床内容”亚型。然后发现这些亚型具有不同的神经生物学途径，这表明需要不同的治疗方法。
