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精神分裂症中的生活事件与复发。一项为期一年的前瞻性研究。

Life events and relapse in schizophrenia. A one year prospective study.

作者信息

Malla A K, Cortese L, Shaw T S, Ginsberg B

机构信息

University of Western Ontario, London, Canada.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 1990 Jul;25(4):221-4. doi: 10.1007/BF00782965.

DOI:10.1007/BF00782965
PMID:2399480
Abstract

Results from a one year prospective study of a relationship between major and minor life events (all other events), and relapse in twenty-two schizophrenic (DSM III-R) patients are reported. Seven (33%) patients relapsed during the one year of follow-up. Relapsed patients had experienced significantly more independent major and minor life events during the one year compared to non-relapsed patients. The independent events experienced by the relapsed patients occurred twice as often in the three month period prior to the relapse as compared to any other period among the relapsed, or the non-relapsed patients. These findings are discussed in the context of the prospective design of this study and the inclusion of minor as well as major events.

摘要

报告了一项针对22名精神分裂症(DSM III-R)患者的重大和轻微生活事件(所有其他事件)与复发之间关系的为期一年的前瞻性研究结果。在一年的随访期间,7名(33%)患者复发。与未复发患者相比,复发患者在这一年中经历的独立重大和轻微生活事件明显更多。复发患者经历的独立事件在复发前三个月的发生频率是复发患者或未复发患者其他任何时期的两倍。将在本研究的前瞻性设计以及纳入轻微和重大事件的背景下讨论这些发现。

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本文引用的文献

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Orexin Modulation of VTA Dopamine Neuron Activity: Relevance to Schizophrenia.食欲素对 VTA 多巴胺神经元活动的调节:与精神分裂症的相关性。
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