Apfelbacher Christian, Molin Sonja, Weisshaar Elke, Bauer Andrea, Elsner Peter, Mahler Vera, Weiss Melanie, Ruzicka Thomas, Diepgen Thomas L
Medical Sociology, Department of Epidemiology and Preventive Medicine, University of Regensburg, DE-93053 Regensburg, Germany.
Acta Derm Venereol. 2014 Mar;94(2):163-7. doi: 10.2340/00015555-1632.
The aim of the CARPE registry is to investigate characteristics and medical care in patients affected by chronic hand eczema. Patients are assessed by dermatological examination and patient questionnaire. Socio-economic and clinical data are collected, and quality of life is measured using the Dermatology Life Quality Index (DLQI). A total of 1,163 patients with chronic hand eczema were eligible for analysis (mean age 47.0 years; 54.6% female; mean disease duration 7.6 years). At inclusion, chronic hand eczema was very severe in 23.4%, severe in 47.0%, moderate in 20.1%, and clear or almost clear in 9.6% of patients. Median DLQI was 8.0. In all, 93.8% of patients reported use of topical corticosteroids, 25.6% systemic antihistamines, 28.3% topical calcineurin-inhibitors, 38.0% ultraviolet phototherapy, and 35.3% systemic treatment (19.7% alitretinoin) prior to inclusion in the registry. A significant proportion of patients may not receive adequate treatment according to the guideline on management of hand eczema.
CARPE注册研究的目的是调查慢性手部湿疹患者的特征及医疗情况。通过皮肤科检查和患者问卷对患者进行评估。收集社会经济和临床数据，并使用皮肤病生活质量指数（DLQI）来衡量生活质量。共有1163例慢性手部湿疹患者符合分析条件（平均年龄47.0岁；54.6%为女性；平均病程7.6年）。纳入时，23.4%的患者慢性手部湿疹非常严重，47.0%为重度，20.1%为中度，9.6%的患者病情清晰或几乎清晰。DLQI中位数为8.0。总体而言，93.8%的患者报告在纳入注册研究之前使用过外用糖皮质激素，25.6%使用过全身性抗组胺药，28.3%使用过外用钙调神经磷酸酶抑制剂，38.0%接受过紫外线光疗，35.3%接受过全身治疗（19.7%使用阿维A）。根据手部湿疹管理指南，相当一部分患者可能未得到充分治疗。
