van Ramshorst Mette S, Struthers Helen E, McIntyre James A, Peters Remco P H
From the *Anova Health Institute, Johannesburg and Tzaneen, South Africa; †Department of Internal Medicine, University of Cape Town; and ‡School of Public Health, University of Cape Town, Cape Town, South Africa.
Pediatr Infect Dis J. 2014 Apr;33(4):393-5. doi: 10.1097/INF.0000000000000036.
We studied blood lactate levels in 253 South African children on antiretroviral therapy. The prevalence of hyperlactatemia was 68% and severity was mild in most cases (69%). There was no association of symptoms and/or signs with hyperlactatemia. Independent predictors were lipo-dystrophy, time on antiretroviral therapy and baseline CD4 count. Increased awareness of hyperlactatemia in African children on antiretroviral therapy is warranted.
我们研究了253名接受抗逆转录病毒治疗的南非儿童的血乳酸水平。高乳酸血症的患病率为68%，大多数病例（69%）症状较轻。高乳酸血症与症状和/或体征之间无关联。独立预测因素为脂肪代谢障碍、抗逆转录病毒治疗时间和基线CD4计数。有必要提高对接受抗逆转录病毒治疗的非洲儿童高乳酸血症的认识。
