Monzón C M, Villavicencio V I
Veterinary Diagnostic and Research Centre-CEDIVEF, Formosa, Argentina.
Vet Parasitol. 1990 Jul;36(3-4):295-301. doi: 10.1016/0304-4017(90)90041-9.
The serum protein pattern in guinea-pigs infected with T. evansi was analysed and compared with those found in horses with either a natural or experimental infection. In both species, a highly significant decrease in albumin levels and an increase in gamma-globulins were seen, leading to a very low albumin/globulin ratio. No significant differences in total protein levels between healthy and infected animals were registered. Likewise, alpha-globulins were not significantly affected. A decrease in beta-globulins was observed in one horse and in guinea-pigs with experimental infection, while in horses with natural infections this decrease was not constant. The serum protein patterns in guinea-pigs infected with T. evansi appeared similar to those occurring in horses infected with this parasite. Guinea-pigs, therefore may be useful laboratory models for the study of equine trypanosomosis caused by T. evansi.
对感染伊氏锥虫的豚鼠血清蛋白模式进行了分析，并与自然感染或实验感染马的血清蛋白模式进行了比较。在这两个物种中，均观察到白蛋白水平显著降低，γ球蛋白增加，导致白蛋白/球蛋白比值非常低。健康动物和感染动物之间的总蛋白水平没有显著差异。同样，α球蛋白也没有受到显著影响。在一匹马和实验感染的豚鼠中观察到β球蛋白减少，而在自然感染的马中，这种减少并不恒定。感染伊氏锥虫的豚鼠血清蛋白模式与感染该寄生虫的马的血清蛋白模式相似。因此，豚鼠可能是研究由伊氏锥虫引起的马锥虫病的有用实验模型。
