IEEE Trans Biomed Eng. 2014 Feb;61(2):246-53. doi: 10.1109/TBME.2013.2279673.
Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral “interior” imaging chain integrated with a traditional wide-beam “global” imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.
光谱 CT 已被证明是生物医学成像领域的一项重要进展，过去几年来已有多篇出版物展示了其在临床前和临床应用中的优势。2012 年，Xu 报道称，通过混合架构可以增强近场实现的光谱微 CT：将窄束光谱“内部”成像链与传统的宽束“全局”成像链集成。这种混合集成与基于压缩感知（CS）的内部层析成像相结合，为提高对比度分辨率、降低系统成本和辐射剂量提供了有前景的结果。本研究的动机是使用首例混合光谱微 CT 系统来实现和评估混合架构。初步结果证实了对比度和空间分辨率的提高。该技术被证明值得进一步研究，并有可能在未来的光谱 CT 扫描仪设计中得到应用。
