Matsumoto Satohiro, Yoshida Yukio
Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan,
Indian J Gastroenterol. 2014 Jan;33(1):46-9. doi: 10.1007/s12664-013-0378-2. Epub 2013 Aug 31.
Although endoscopic screening has become more common in recent years, its efficacy in reducing the mortality from gastric cancer has not yet been demonstrated. We carried out a case-control study to evaluate the efficacy of endoscopic screening in Kamigoto town, Kamigoto Island. The case group consisted of 13 patients who died of gastric cancer between 2000 and 2008, and ten controls per patient, ie. a total of 130 controls, were extracted as the control group. To clarify the relationship between participation in endoscopic screening and gastric cancer mortality, the odds ratio of death from gastric cancer in participants vs. nonparticipants of screening was calculated. The odds ratio of death from gastric cancer in participants of endoscopic screening vs. nonparticipants was 0.206 (95 % CI, 0.044-0.965; p = 0.0449). Participation in endoscopic screening within the previous 5 years decreased the risk of death from gastric cancer by 79 %. Implementation of endoscopic screening was associated with a significant reduction in mortality from gastric cancer in the small island town.
尽管近年来内镜筛查已变得更为普遍，但其在降低胃癌死亡率方面的疗效尚未得到证实。我们开展了一项病例对照研究，以评估在神戸岛神戸町进行内镜筛查的疗效。病例组由2000年至2008年间死于胃癌的13例患者组成，为每位患者抽取10名对照，即总共130名对照作为对照组。为阐明参与内镜筛查与胃癌死亡率之间的关系，计算了筛查参与者与非参与者中死于胃癌的比值比。内镜筛查参与者与非参与者中死于胃癌的比值比为0.206（95%可信区间，0.044 - 0.965；p = 0.0449）。在过去5年内参与内镜筛查使死于胃癌的风险降低了79%。在内镜筛查在这个小岛镇的实施与胃癌死亡率的显著降低相关。
