Kuvshinnikov V A
Vopr Pitan. 1990 May-Jun(3):24-8.
The nutritive status features and the main parameters of nitrogen metabolism were investigated in 212 children with acute leukemia at varying stages of the disease. A study was made of the patients' body mass, nitrogen balance, excretion of nitrogenous compounds with urine and feces, total protein and albumin content in the blood, as well as blood content of urea, creatinine, amino nitrogen and uric acid. The results of the study have shown a negative influence of both leukemia and its therapy on the nutritive status of the patients, that was manifested in protein-energy deficiency and in protein assimilation disorders. A relationship has been revealed between infectious complications, preventing the successful treatment, and the nutritive status of the patients. Clarification of these pathogenetic mechanisms of the negative action of the disease itself and antileukemic therapy will help in the realization of the purposeful correction.
对212名处于疾病不同阶段的急性白血病患儿的营养状况特征及氮代谢主要参数进行了研究。对患者的体重、氮平衡、尿粪中含氮化合物的排泄、血液中的总蛋白和白蛋白含量以及尿素、肌酐、氨基氮和尿酸的血液含量进行了研究。研究结果表明，白血病及其治疗均对患者的营养状况产生负面影响，表现为蛋白质 - 能量缺乏和蛋白质同化障碍。已揭示出妨碍成功治疗的感染并发症与患者营养状况之间的关系。阐明疾病本身和抗白血病治疗负面作用的这些发病机制将有助于实现有针对性的纠正。
