Charlin de G V, Carrasco F, Kehr J, Defilipi C, Vargas V, Ferrer L, Ferrer E, Morales B, Gómez E
Departamento de Nutrición, Universidad de Chile, Santiago.
Rev Med Chil. 1995 Sep;123(9):1091-7.
To study the relationship between the changes in protein repletion indicators and calorie and nitrogen balance in undernourished patients receiving enteral nutrition.
Fourteen patients (11 female, age range 55-85 years old) with an initial serum albumin below 3.5 g/dl or serum transferrin below 200 mg/dl, which received enteral nutrition, were studied. On days one and ten of nutritional support, indirect calorimetry, nitrogen balance and serum levels of albumin, transferrin, pre-albumin and total lymphocyte count were measured.
Initial resting energy expenditure was 25.1 +/- 5 Kcal/kg/day (115.4 +/- 20% of that predicted by Harris Benedict equations) and urinary urea nitrogen 5.4 +/- 3.7 g/day. Initial and final nitrogen balances were 66.9 +/- 71 and 81.4 +/- 105.9 mg N/kg/day and mean energy balance throughout the study was +9.0 +/- 7.2 Kcal/kg/day. During the ten days of nutritional support, albumin improved significantly in 0.35 +/- 0.43 g/dl (15.2 +/- 19.8%). Transferrin, pre-albumin and total lymphocyte count did not change significantly. The changes in these last parameters did not correlate with nitrogen or calorie balance.
Probably other factors, besides nutritional balances, influence serum protein levels and these may not change despite an adequate nutritional repletion.
研究接受肠内营养的营养不良患者蛋白质补充指标变化与热量及氮平衡之间的关系。
对14例初始血清白蛋白低于3.5 g/dl或血清转铁蛋白低于200 mg/dl且接受肠内营养的患者（11例女性，年龄范围55 - 85岁）进行研究。在营养支持的第1天和第10天，测量间接测热法、氮平衡以及白蛋白、转铁蛋白、前白蛋白的血清水平和总淋巴细胞计数。
初始静息能量消耗为25.1±5千卡/千克/天（为哈里斯-本尼迪克特方程预测值的115.4±20%），尿尿素氮为5.4±3.7克/天。初始和最终氮平衡分别为66.9±71和81.4±105.9毫克氮/千克/天，整个研究期间的平均能量平衡为+9.0±7.2千卡/千克/天。在营养支持的10天里，白蛋白显著改善了0.35±0.43 g/dl（15.2±19.8%）。转铁蛋白、前白蛋白和总淋巴细胞计数无显著变化。这些最后参数的变化与氮或热量平衡无关。
除营养平衡外，可能还有其他因素影响血清蛋白水平，即便营养补充充足，这些因素也可能不会改变。
