Boss Lisa, Kang Duck-Hee, Marcus Marianne, Bergstrom Nancy
1University of Texas Health Science Center at Houston, USA.
West J Nurs Res. 2014 Mar;36(3):388-426. doi: 10.1177/0193945913500566. Epub 2013 Aug 29.
Estrogen and testosterone may influence cognition in older adults, but the relationship between sex hormones and cognitive function is complex. The aim of this systematic review is to examine the role of sex hormones in cognitive function among older adults. A comprehensive, electronic review of literature was performed. Inclusion criteria were original quantitative research, written in English, used human subjects with a mean age of ≥60 years, and published from January 1997 through May 2012. Findings were mixed, although potential patterns were identified. Estradiol levels were potentially associated with benefits to episodic memory, semantic memory, verbal memory, and verbal learning in females only. The association between testosterone and cognitive function was mixed in both genders. Mixed findings may have been influenced by methodological differences and future studies should include research designs with ample rigor, sufficiently powered samples, consistent cognitive measurements, and clear descriptions of handling and storage of biological specimens.
雌激素和睾酮可能会影响老年人的认知，但性激素与认知功能之间的关系很复杂。本系统评价的目的是研究性激素在老年人认知功能中的作用。我们对文献进行了全面的电子检索。纳入标准为：原创性定量研究、英文撰写、使用平均年龄≥60岁的人类受试者，且发表于1997年1月至2012年5月期间。研究结果不一，不过也发现了一些潜在模式。仅在女性中，雌二醇水平可能与情景记忆、语义记忆、言语记忆和言语学习方面的益处有关。睾酮与认知功能之间的关联在两性中都存在差异。研究结果不一可能受到了方法学差异的影响，未来的研究应采用严谨的研究设计、样本量充足、认知测量一致，并对生物样本的处理和储存进行清晰描述。
