Program in Membrane Biology, Center for Systems Biology, Nephrology Division, Massachusetts General Hospital, Boston, MA, USA.
Physiology (Bethesda). 2013 Sep;28(5):318-29. doi: 10.1152/physiol.00007.2013.
Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility. This review focuses on the regulation of V-ATPase-dependent luminal acidification in renal intercalated cells and epididymal clear cells, which are key players in these physiological processes.
体内的特化细胞在其质膜中表达高水平的 V-ATPase，并对激素和非激素信号做出反应，以调节细胞外酸化。一些 V-ATPase 亚基的突变或缺失会导致几种疾病，包括肾远曲小管酸中毒和男性不育。这篇综述重点介绍了 V-ATPase 依赖性管腔酸化在肾闰细胞和附睾清亮细胞中的调节，这两种细胞是这些生理过程中的关键参与者。
