Jesmin Mele, Ali M Mohsin, Salahuddin M S, Habib M Rowshanul, Khanam Jahan Ara
Department of Applied Chemistry and Chemical Technology, Rajshahi University, Rajshahi-6205, Bangladesh.
Mycobiology. 2008 Mar;36(1):70-3. doi: 10.4489/MYCO.2008.36.1.070. Epub 2008 Mar 31.
The antibacterial and antifungal activities of three schiff bases were evaluated against some pathogenic bacteria and fungi. Parallel experiments were also carried out with standard drugs (Kanamycin for bacteria and Nystatin for fungi). Two compounds [N-(1-phenyl-2-hydroxy-2phenylethylidine)-2',4' dinitrophenyl hydrazine, abbreviated as PDH and N-(2-hydroxy benzylidine)-2'-hydroxy imine, abbreviated as HHP] showed significant antimicrobial activities. The rest one [N-(1-phenyl 2-hydroxy-2 phenyl ethylidine) 2'-hydroxy phenyl imine, abbreviated as PHP] showed moderate activity. All these three compounds were found to possess pronounced cytotoxic effect. These compounds can be considered as potent antimicrobial agents.
评估了三种席夫碱对一些病原菌和真菌的抗菌和抗真菌活性。同时也使用标准药物（用于细菌的卡那霉素和用于真菌的制霉菌素）进行了平行实验。两种化合物[N-(1-苯基-2-羟基-2-苯基亚乙基)-2',4'-二硝基苯肼，简称为PDH和N-(2-羟基苄叉)-2'-羟基亚胺，简称为HHP]表现出显著的抗菌活性。其余一种[N-(1-苯基-2-羟基-2-苯乙基) -2'-羟基苯亚胺，简称为PHP]表现出中等活性。发现所有这三种化合物都具有明显的细胞毒性作用。这些化合物可被视为有效的抗菌剂。
