丙酮缩氨基脲对实验小鼠艾氏腹水癌诱发致癌作用的肝保护效应。
Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice.
作者信息
Islam Farhadul, Ali Shaikh Mohummad Mohsin, Khanam Jahan Ara
机构信息
Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh.
出版信息
Asian Pac J Trop Biomed. 2013 Feb;3(2):105-10. doi: 10.1016/S2221-1691(13)60033-7.
OBJECTIVE
To determine the hepatoprotective effect of acetone semicarbazone (ASC) in vivo in normal and Ehrlich ascites carcinoma (EAC) bearing male Swiss albino mice.
METHODS
Drug-induced changes in biochemical and behavioral parameters at dose of 2.0 mg/kg body weight for 14 d and nullifying the toxicity induced by EAC cells were studied. The histopathology studies of the protective effects of ASC on vital organs were also assessed.
RESULTS
The administration of ASC made insignificant changes in body weight and behavioral (salivation, diarrhea, muscular numbness) changes during treatment period due to minor toxicity were minimized after the treatment in normal mice. The biochemical parameters, including serum glutamate pyruvate transaminase, glutamate oxaloactate transaminase, alkaline phosphatase, serum glucose, cholesterol, urea, triglyceride and billirubin changed modestly in normal mice receiving ASC. Though the treatment continued, these values gradually decreased to normal level after the treatment. In EAC bearing mice, the toxic effects due to EAC cells in all cases were nullified by treatment with the ASC. Significant abnormalities were not detected in histology of the various organs of the normal mice treated with ASC.
CONCLUSIONS
ASC can, therefore, be considered safe in formulating novel anticancer drug, as it exhibits strong protective effect against EAC cell bearing mice.
目的
确定丙酮缩氨基脲（ASC）在正常雄性瑞士白化小鼠和荷艾氏腹水癌（EAC）小鼠体内的肝保护作用。
方法
研究了以2.0 mg/kg体重的剂量给药14天对生化和行为参数的药物诱导变化以及消除EAC细胞诱导的毒性。还评估了ASC对重要器官保护作用的组织病理学研究。
结果
在正常小鼠中，给药ASC后体重变化不显著，且治疗期间因轻微毒性引起的行为变化（流涎、腹泻、肌肉麻木）在治疗后降至最低。接受ASC的正常小鼠的生化参数，包括血清谷丙转氨酶、谷草转氨酶、碱性磷酸酶、血清葡萄糖、胆固醇、尿素、甘油三酯和胆红素均有适度变化。尽管治疗持续进行，但这些值在治疗后逐渐降至正常水平。在荷EAC小鼠中，用ASC治疗消除了EAC细胞在所有情况下的毒性作用。用ASC治疗的正常小鼠的各种器官组织学未检测到明显异常。
结论
因此，ASC在配制新型抗癌药物时可被认为是安全的，因为它对荷EAC细胞的小鼠具有强大的保护作用。
Zotero 插件