• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones.2-乙酰吡啶缩氨基硫脲对临床上重要细菌菌株的体外抑制作用。
Antimicrob Agents Chemother. 1980 Jul;18(1):27-36. doi: 10.1128/AAC.18.1.27.
2
Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1- and 3-acetylisoquinoline and related compounds as inhibitors of clinically significant bacteria in vitro.2-乙酰吡啶、2-乙酰喹啉、1-和3-乙酰异喹啉的硫代氨基脲及其相关化合物作为体外临床重要细菌的抑制剂。
Arzneimittelforschung. 1983;33(11):1583-91.
3
Antibacterial properties of 2-acetylpyridine-1-oxide thiosemicarbazones.2-乙酰基吡啶-1-氧化物缩氨基硫脲的抗菌特性
Chemotherapy. 1986;32(1):25-30. doi: 10.1159/000238385.
4
2-Acetylpyridine thiosemicarbazones XI: 2-(alpha-Hydroxyacetyl)pyridine thiosemicarbazones as antimalarial and antibacterial agents.
J Pharm Sci. 1984 Dec;73(12):1763-7. doi: 10.1002/jps.2600731226.
5
In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones.淋病奈瑟菌对2-乙酰吡啶硫代氨基脲的体外敏感性
Antimicrob Agents Chemother. 1985 Apr;27(4):570-3. doi: 10.1128/AAC.27.4.570.
6
[In vitro activity of imipenem against hospital bacteria].
Presse Med. 1990 Apr 4;19(13):583-7.
7
In vitro activity of PD 117596-2, a broad-spectrum difluoroquinolone.广谱二氟喹诺酮PD 117596-2的体外活性
Eur J Clin Microbiol Infect Dis. 1989 Jul;8(7):644-50. doi: 10.1007/BF01968149.
8
Minimum inhibitory concentration determinations for various antimicrobial agents against 1570 bacterial isolates from turkey poults.对来自小火鸡的1570株细菌分离株进行多种抗菌剂的最低抑菌浓度测定。
Avian Dis. 2000 Jan-Mar;44(1):85-98.
9
[On the effect of hexetidine in vitro].[关于海克替啶的体外作用]
Arzneimittelforschung. 1969 Feb;19(2):164-7.
10
Comparison of the in vitro activity of azlocillin and carbenicillin against 856 clinical bacterial isolates.阿洛西林和羧苄西林对856株临床分离菌的体外活性比较。
NIPH Ann. 1984 Jun;7(1):13-9.

引用本文的文献

1
Co(ii), Ni(ii), Cu(ii) and Cd(ii)-thiocarbonohydrazone complexes: spectroscopic, DFT, thermal, and electrical conductivity studies.钴（II）、镍（II）、铜（II）和镉（II）-硫代碳酰肼配合物：光谱、密度泛函理论、热学及电导率研究
RSC Adv. 2021 Nov 23;11(60):37726-37743. doi: 10.1039/d1ra06902k.
2
In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone.一种甲氧基-苯乙烯基-缩氨基硫脲的体外和体内细胞毒性活性及与人血清白蛋白的相互作用。
Invest New Drugs. 2019 Oct;37(5):994-1005. doi: 10.1007/s10637-018-00722-y. Epub 2019 Jan 19.
3
Screening organometallic thiophene containing thiosemicarbazone ruthenium (II/III) complexes as potential anti-tumour agents.筛选含噻吩并半卡巴腙的有机金属钌（II/III）配合物作为潜在的抗肿瘤剂。
J Biol Inorg Chem. 2018 May;23(3):425-435. doi: 10.1007/s00775-018-1549-5. Epub 2018 Mar 22.
4
Antimicrobial activity of some schiff bases derived from benzoin, salicylaldehyde, aminophenol and 2,4 dinitrophenyl hydrazine.一些由安息香、水杨醛、氨基酚和2,4-二硝基苯肼衍生的席夫碱的抗菌活性。
Mycobiology. 2008 Mar;36(1):70-3. doi: 10.4489/MYCO.2008.36.1.070. Epub 2008 Mar 31.
5
Adsorption and quantum chemical studies on the inhibition potentials of some thiosemicarbazides for the corrosion of mild steel in acidic medium.一些硫代氨基脲对酸性介质中低碳钢腐蚀的抑制电位的吸附和量子化学研究。
Int J Mol Sci. 2010 Jun 15;11(6):2473-98. doi: 10.3390/ijms11062473.
6
Iron and Cobalt Complexes of 2,6-Diacetylpyridine-bis(R-thiosemicarbazone) (R=H, phenyl) Showing Unprecedented Ligand Deviation from Planarity.2,6-二乙酰基吡啶-双（R-硫代半卡巴腙）（R = H，苯基）的铁和钴配合物呈现出前所未有的配体偏离平面性。
Inorganica Chim Acta. 2009 Mar 2;362(4):1348-1354. doi: 10.1016/j.ica.2008.06.031.
7
Synthesis and structure-activity correlation studies of metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones in Shewanella oneidensis.嗜铁钩端螺旋菌中α-N-杂环羧醛缩氨基硫脲金属配合物的合成及构效关系研究
Int J Environ Res Public Health. 2005 Apr;2(1):170-4. doi: 10.3390/ijerph2005010170.
8
Activity of 2-acetylpyridine thiosemicarbazones against Trypanosoma rhodesiense in vitro.2-乙酰基吡啶硫代半卡巴腙对罗德西亚锥虫的体外活性
Antimicrob Agents Chemother. 1980 Aug;18(2):317-22. doi: 10.1128/AAC.18.2.317.
9
Antiviral activity of 2-acetylpyridine thiosemicarbazones against herpes simplex virus.2-乙酰基吡啶硫代半卡巴腙对单纯疱疹病毒的抗病毒活性
Antimicrob Agents Chemother. 1981 Apr;19(4):682-5. doi: 10.1128/AAC.19.4.682.
10
Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties.一种具有抗菌和抗寄生虫特性的新型硫代卡巴腙对核糖核酸合成的优先抑制作用。
Antimicrob Agents Chemother. 1981 Feb;19(2):234-7. doi: 10.1128/AAC.19.2.234.

本文引用的文献

1
NEISSERIA GONORRHOEAE IDENTIFICATION IN DIRECT SMEARS BY A FLUORESCENT ANTIBODY-COUNTERSTAIN METHOD.采用荧光抗体复染法对直接涂片进行淋病奈瑟菌鉴定。
Appl Microbiol. 1965 Mar;13(2):171-4. doi: 10.1128/am.13.2.171-174.1965.
2
ABORTIVE INTESTINAL INFECTION WITH AN ESCHERICHIA COLI-SHIGELLA FLEXNERI HYBRID STRAIN.由大肠埃希菌-福氏志贺菌杂交菌株引起的顿挫型肠道感染
J Bacteriol. 1965 May;89(5):1374-82. doi: 10.1128/jb.89.5.1374-1382.1965.
3
Concentrated culture of gonococci in clear liquid medium.淋病奈瑟菌在清亮液体培养基中的浓缩培养物。
Proc Soc Exp Biol Med. 1960 Oct;105:49-51. doi: 10.3181/00379727-105-26005.
4
Apparatus for phagetyping of Staphylococcus aureus.金黄色葡萄球菌噬菌体型分型装置。
Mon Bull Minist Health Public Health Lab Serv. 1959 Mar;18:49-52.
5
Chemotherapeutics with tuberculostatic action.具有抑菌作用的化疗药物。
Antibiot Chemother (1971). 1971;17:101-21. doi: 10.1159/000392367.
6
[Studies on the tuberculostatic activity on new benzaledhyde and thiophene-aldehyde thiosemicarbazones in vitro and in vivo].新型苯甲醛及噻吩醛缩氨基硫脲体外及体内抗结核活性的研究
Arzneimittelforschung. 1972 Oct;22(10):1713-6.
7
Leprosy. A preliminary review of the experimental evaluation of drugs for the treatment of leprosy.
Trans R Soc Trop Med Hyg. 1967;61(4):581-95. doi: 10.1016/0035-9203(67)90111-3.
8
2-Acetylpyridine thiosemicarbazones. 2. N4,N4-Disubstituted derivatives as potential antimalarial agents.2-乙酰基吡啶硫代半卡巴腙。2. N4,N4-二取代衍生物作为潜在的抗疟药。
J Med Chem. 1979 Nov;22(11):1367-73. doi: 10.1021/jm00197a017.
9
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents.2-乙酰吡啶硫代半卡巴腙。1. 一类新型潜在抗疟药。
J Med Chem. 1979 Jul;22(7):855-62. doi: 10.1021/jm00193a020.

2-乙酰吡啶缩氨基硫脲对临床上重要细菌菌株的体外抑制作用。

Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones.

作者信息

Dobek A S, Klayman D L, Dickson E T, Scovill J P, Tramont E C

出版信息

Antimicrob Agents Chemother. 1980 Jul;18(1):27-36. doi: 10.1128/AAC.18.1.27.

DOI:10.1128/AAC.18.1.27
PMID:7416748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283934/
Abstract

Antibacterial activity of 65 2-acetylpyridine thiosemicarbazones and related compounds was determined by using clinical isolates of nine bacterial genera. Minimal inhibitory concentrations (MICs) of 0.002 to 0.062 micrograms/ml were obtained with 23% of the compounds for Neisseria gonorrhoeae and 0.016 to 0.062 micrograms/ml with 17% of the compounds for N. meningitidis. Staphylococcus aureus was inhibited in the MIC range of 0.125 to 0.5 micrograms/ml by 18% of the thiosemicarbazones, whereas 26% inhibited group D enterococcus with an MIC of 0.25 to 2.0 micrograms/ml. Poor antibacterial activity was shown toward the gram-negative bacilli, i.e., Pseudomonas, Klebsiella-Enterobacter, Shigella, Escherichia coli, and Proteus.

摘要

利用9个细菌属的临床分离菌株测定了65种2-乙酰基吡啶硫代半卡巴腙及相关化合物的抗菌活性。23%的化合物对淋病奈瑟菌的最低抑菌浓度（MIC）为0.002至0.062微克/毫升，17%的化合物对脑膜炎奈瑟菌的MIC为0.016至0.062微克/毫升。18%的硫代半卡巴腙对金黄色葡萄球菌的MIC范围为0.125至0.5微克/毫升，而26%的硫代半卡巴腙对D组肠球菌的MIC为0.25至2.0微克/毫升。对革兰氏阴性杆菌，即假单胞菌、克雷伯菌-肠杆菌、志贺菌、大肠杆菌和变形杆菌，显示出较弱的抗菌活性。