NMR Laboratory, Department of Neurology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Transl Stroke Res. 2012 Mar;3(1):56-64. doi: 10.1007/s12975-011-0133-.
Quantitative measurement of blood-brain barrier (BBB) permeability using MRI and its application to cerebral ischemia are reviewed. Measurement of BBB permeability using MRI has been employed to evaluate ischemic damage during acute and subacute phases of stroke and to predict hemorrhagic transformation. There is also an emerging interest on the development and use of MRI to monitor vascular structural changes and angiogenesis during stroke recovery. In this review, we describe MRI BBB permeability and susceptibility-weighted MRI measurements and its applications to evaluate ischemic damage during the acute and subacute phases of stroke and vascular remodeling during stroke recovery.
本文综述了 MRI 用于测量血脑屏障（BBB）通透性及其在脑缺血中的应用。MRI 用于测量 BBB 通透性已被用于评估中风急性期和亚急性期的缺血损伤，并预测出血性转化。人们对开发和使用 MRI 来监测中风恢复过程中的血管结构变化和血管生成也越来越感兴趣。在这篇综述中，我们描述了 MRI BBB 通透性和磁敏感加权 MRI 测量及其在评估中风急性期和亚急性期的缺血损伤以及中风恢复过程中的血管重塑中的应用。
