K Agrawal, Bh Paudel, Pn Singh, S Majhi, Hp Pokhrel
Department of Physiology, BPKIHS , Dharan, Nepal .
J Clin Diagn Res. 2013 Jul;7(7):1319-21. doi: 10.7860/JCDR/2013/6040.3136. Epub 2013 Jul 1.
Pregnancy is accompanied by profound alterations in the thyroid economy and the relative iodine deficiency. The median Urinary Iodine Excretion (UIE) is the most reliable indicator of the population's iodine nutrition. The physiological alterations in normal pregnancy, such as an increased glomerular filtration rate, potentially invalidate UIE as an assessment tool in pregnancy.
To assess the Urinary Iodine Excretion (UIE) in pregnant mothers and to enquire about the current status of their iodised salt intake.
We carried out a cross-sectional study in which urine samples were collected from 45 pregnant mothers who were admitted to the antenatal ward. The iodine level in the urine was analysed by a method which was provided by Singh and Ali, to determine the Urinary Iodine Excretion (UIE). A questionnaire was introduced to document the status of the dietary intake of iodised salt. The UIE was expressed in median (interquartile) and the other data are expressed in frequency and percentage. Fisher Exact test was applied to compare between UIE and iodine intake.
Thirteen (28.88%) pregnant mothers had UIEs of <150 μg/L, which were below the cut-off point of the UIE for pregnant mothers. Overall, 33 mothers were from the Terai region; among them, one third had UIEs of <150 μg/L. Among the 45 pregnant women, 15 (33.34%) were not using iodised salt and the rest were using iodised salt. Among those who were using iodised salt (30 out of 45), 8 pregnant women had UIEs of <150 μg/L and among those who were not using iodised salt, 5 pregnant women had UIEs of < 150 μg/L.
The UIE was below 150μg/L in a substantial percentage (28.89%) of pregnant women of the Terai region, regardless of their intake of iodised salt.
妊娠伴随着甲状腺功能和相对碘缺乏的深刻变化。尿碘排泄中位数（UIE）是人群碘营养最可靠的指标。正常妊娠中的生理变化，如肾小球滤过率增加，可能使UIE作为妊娠评估工具无效。
评估孕妇的尿碘排泄量（UIE），并询问她们碘盐摄入的现状。
我们进行了一项横断面研究，从45名入住产前病房的孕妇中收集尿液样本。采用Singh和Ali提供的方法分析尿液中的碘水平，以确定尿碘排泄量（UIE）。引入一份问卷来记录碘盐饮食摄入情况。UIE以中位数（四分位间距）表示，其他数据以频率和百分比表示。应用Fisher精确检验比较UIE和碘摄入量。
13名（28.88%）孕妇的UIE<150μg/L，低于孕妇UIE的切点。总体而言，33名母亲来自特赖地区；其中三分之一的母亲UIE<150μg/L。在45名孕妇中，15名（33.34%）未使用碘盐，其余孕妇使用碘盐。在使用碘盐的孕妇（45名中的30名）中，8名孕妇的UIE<150μg/L，在未使用碘盐的孕妇中，5名孕妇的UIE<150μg/L。
特赖地区相当比例（28.89%）的孕妇UIE低于150μg/L，无论其碘盐摄入量如何。
