Primary Health Care Center, Tornio, Finland.
Best Pract Res Clin Gastroenterol. 2013 Jun;27(3):325-37. doi: 10.1016/j.bpg.2013.06.008.
Gastro-oesophageal reflux disease (GORD) occurs when reflux of gastric contents causes troublesome symptoms and/or complications (the Montreal definition). GORD is a common condition with a substantial economical burden to the community and it has a significant negative effect on health-related quality of life (HRQoL) while endoscopic findings like erosive oesophagitis per se seem to correlate badly with the experienced HRQoL. The prevalence of GORD varies over the world for unknown reasons, but genetic differences, difference in the Helicobacter pylori prevalence and life style factors like obesity might influence. The prevalence is lowest in East Asia (2.5-9.4%) and higher in Mid (7.6-19.4%) and Western Asia (12.5-27.6%). The highest population-based prevalence is reported from Europe (23.7%) and the US (28.8%). GORD seems to be fairly stable over time both in terms of symptoms and erosive oesophagitis, but the prevalence seems to be increasing both in Asia and in the West.
胃食管反流病（GORD）是指胃内容物反流引起不适症状和/或并发症（蒙特利尔定义）。GORD 是一种常见疾病，给社区带来了巨大的经济负担，它对健康相关生活质量（HRQoL）有显著的负面影响，而内镜下发现的食管炎本身似乎与所经历的 HRQoL 相关性较差。由于未知原因，GORD 在世界各地的患病率不同，但遗传差异、幽门螺杆菌流行率的差异以及肥胖等生活方式因素可能会产生影响。在东亚（2.5-9.4%），GORD 的患病率最低，在中东（7.6-19.4%）和西亚（12.5-27.6%）则较高。基于人群的最高患病率报道来自欧洲（23.7%）和美国（28.8%）。无论是症状还是糜烂性食管炎，GORD 在一段时间内似乎都相当稳定，但在亚洲和西方，其患病率似乎都在上升。
