围绝经期妇女代谢综合征与慢性肾脏病的关系。
Association between metabolic syndrome and chronic kidney disease in perimenopausal women.
机构信息
Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
出版信息
Int J Environ Res Public Health. 2013 Aug 30;10(9):3987-97. doi: 10.3390/ijerph10093987.
The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ≤ Age < 50 years old; Group 2, 50 years old ≤ Age < 60 years old; Group 3, 60 years old ≤ Age ≤ 65 years old. MetS was associated with CKD (p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD (p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28-16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD (p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10-12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD (p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65.
本研究旨在探讨围绝经期妇女中代谢综合征（MetS）与慢性肾脏病（CKD）之间的关系。2012 年 6 月至 10 月在珠海进行了一项横断面研究。将 685 名围绝经期妇女纳入研究。所有参与者被分为三组：组 1，年龄 40 岁≤年龄<50 岁；组 2，年龄 50 岁≤年龄<60 岁；组 3，年龄 60 岁≤年龄≤65 岁。在未调整的分析中，代谢综合征与 CKD 相关（p<0.01）。在调整潜在混杂因素后，代谢综合征与 CKD 的比值比为 2.66（95%可信区间 1.56 至 4.49，p<0.001）。组 1 和组 3 中代谢综合征与 CKD 之间无相关性。在未调整的分析中，组 2 代谢综合征与 CKD 相关（p<0.001）。在调整潜在混杂因素后，代谢综合征与 CKD 显著相关。代谢综合征的比值比为 6.79（95%可信区间 2.30 至 20.09，p<0.001）。组 1 和组 3 中，高血压、空腹血糖升高、腹型肥胖、低高密度脂蛋白胆固醇血症、高甘油三酯血症与 CKD 之间均无相关性。在组 2 中，高血压与 CKD 相关（未经调整的比值比：4.52（1.28-16.02），p=0.02）。调整潜在混杂因素后，高血压与 CKD 之间无相关性（p=0.78）。在组 2 中，空腹血糖升高与 CKD 相关（未经调整的比值比：3.69（1.10-12.38），p=0.03）。调整潜在混杂因素后，空腹血糖升高与 CKD 之间无相关性（p=0.15）。在组 2 中，腹型肥胖、低高密度脂蛋白胆固醇血症、高甘油三酯血症与 CKD 之间均无相关性。这些结果表明，在 50 岁或以上至 60 岁的围绝经期妇女中，代谢综合征与 CKD 相关。在 40 岁或以上至 50 岁和 60 岁或以上至 65 岁的围绝经期妇女中，代谢综合征与 CKD 之间无相关性。
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