Mendy Vincent L, Azevedo Mario J, Sarpong Daniel F, Rosas Sylvia E, Ekundayo Olugbemiga T, Sung Jung Hye, Bhuiyan Azad R, Jenkins Brenda C, Addison Clifton
Department of Epidemiology and Biostatistics, School of Health Sciences, College of Public Service, Jackson State University, Jackson, Mississippi, United States of America.
Department of Epidemiology and Biostatistics, School of Health Sciences, College of Public Service, Jackson State University, Jackson, Mississippi, United States of America; RTRN Data Coordinating Center, Jackson State University, Jackson, Mississippi, United States of America.
PLoS One. 2014 Jul 3;9(7):e101610. doi: 10.1371/journal.pone.0101610. eCollection 2014.
Approximately 26.3 million people in the United States have chronic kidney disease and many more are at risk of developing the condition. The association between specific metabolic syndrome components and chronic kidney disease in African American individuals is uncertain.
Baseline data from 4,933 participants of the Jackson Heart Study were analyzed. Logistic regression models were used to estimate the odds and 95% confidence intervals of chronic kidney disease associated with individual components, metabolic syndrome, the number of components, and specific combinations of metabolic syndrome components.
Metabolic syndrome was common with a prevalence of 42.0%. Chronic kidney disease was present in 19.4% of participants. The prevalence of metabolic components was high: elevated blood pressure (71.8%), abdominal obesity (65.8%), low fasting high density lipoprotein cholesterol (37.3%), elevated fasting glucose (32.2%) and elevated triglycerides (16.2%). Elevated blood pressure, triglycerides, fasting blood glucose, and abdominal obesity were significantly associated with increased odds of chronic kidney disease. Participants with metabolic syndrome had a 2.22-fold (adjusted odds ratio (AOR) 2.22; 95% CI, 1.78-2.78) increase in the odds of chronic kidney disease compared to participants without metabolic syndrome. The combination of elevated fasting glucose, elevated triglycerides, and abdominal obesity was associated with the highest odds for chronic kidney disease (AOR 25.11; 95% CI, 6.94-90.90).
Metabolic syndrome as well as individual or combinations of metabolic syndrome components are independently associated with chronic kidney disease in African American adults.
美国约有2630万人患有慢性肾脏病，更多人有患此病的风险。非裔美国人中特定代谢综合征成分与慢性肾脏病之间的关联尚不确定。
对杰克逊心脏研究中4933名参与者的基线数据进行分析。采用逻辑回归模型估计与个体成分、代谢综合征、成分数量以及代谢综合征成分的特定组合相关的慢性肾脏病的比值比和95%置信区间。
代谢综合征很常见，患病率为42.0%。19.4%的参与者患有慢性肾脏病。代谢成分的患病率很高：高血压（71.8%）、腹型肥胖（65.8%）、空腹高密度脂蛋白胆固醇降低（37.3%）、空腹血糖升高（32.2%）和甘油三酯升高（16.2%）。高血压、甘油三酯、空腹血糖升高和腹型肥胖与慢性肾脏病的比值比增加显著相关。与没有代谢综合征的参与者相比，患有代谢综合征的参与者患慢性肾脏病的比值比增加了2.22倍（调整后的比值比[AOR]为2.22；95%置信区间为1.78 - 2.78）。空腹血糖升高、甘油三酯升高和腹型肥胖的组合与慢性肾脏病的最高比值比相关（AOR为25.11；95%置信区间为6.94 - 90.90）。
代谢综合征以及代谢综合征成分的个体或组合与非裔美国成年人的慢性肾脏病独立相关。
