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本文引用的文献

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Determination of aqueous solubility by heating and equilibration: A technical note.通过加热和平衡法测定水溶性：技术说明
AAPS PharmSciTech. 2006 Mar;7(1):E29-E32. doi: 10.1208/pt070104. Epub 2017 Mar 8.
2
Exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats.外源性睾酮、非那雄胺及去势对成年雄性大鼠睾酮、胰岛素、锌和铬的影响。
Iran Biomed J. 2013;17(1):49-53. doi: 10.6091/ibj.1110.2012.
3
A new simple and high-yield synthesis of 5α-dihydrotestosterone (DHT), a potent androgen receptor agonist.一种新的 5α-二氢睾酮（DHT）的简单高产合成方法，DHT 是一种有效的雄激素受体激动剂。
Steroids. 2012 Dec;77(14):1530-4. doi: 10.1016/j.steroids.2012.09.003. Epub 2012 Oct 5.
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Sex steroids and the thyroid.性激素与甲状腺。
Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):769-80. doi: 10.1016/j.beem.2009.06.005.
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Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus.新生期甲状腺功能减退对雄性金黄地鼠生殖的影响
Physiol Behav. 2007 Apr 23;90(5):771-81. doi: 10.1016/j.physbeh.2006.12.017. Epub 2007 Jan 13.
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Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation.
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Effects of the chronic use of finasteride on testicular weight and spermatogenesis in Wistar rats.非那雄胺长期使用对Wistar大鼠睾丸重量和精子发生的影响。
BJU Int. 2002 Jun;89(9):961-3. doi: 10.1046/j.1464-410x.2002.02785.x.
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Sex steroids regulate TSH-induced thyroid growth during sexual maturation in Wistar rats.
Exp Clin Endocrinol Diabetes. 2002 Jan;110(1):37-42. doi: 10.1055/s-2002-19993.
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Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men.对年轻男性每日使用非那雄胺进行长期治疗不会影响精子发生或精液生成。
J Urol. 1999 Oct;162(4):1295-300.
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外源性睾酮、非那雄胺及去势对血清甲状腺素水平的影响。

Effect of exogenous testosterone, finasteride, and castration on serum level of thyroxin.

作者信息

Zarei Fatemeh, Yousofvand Namdar, Khazaei Mozafar, Ghanbari Ali

机构信息

Dept. of Biology, Faculty of Science, Razi University, Daneshgah St., Tagh-e-Bostan, Kermanshah, Iran.

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Iran Biomed J. 2013;17(4):221-4. doi: 10.6091/ibj.1234.2013.

DOI:10.6091/ibj.1234.2013
PMID:23999719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3882926/
Abstract

BACKGROUND

The secretion of thyroxin (T4) as the main hormone of thyroid gland is regulated by androgens. The present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of T4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate.

METHODS

Male adult rats (n = 32) were divided into 4 groups (n = 8): Group 1 (control), Group 2 (castration), Group 3 (finasteride: 20 mg/kg/day) and Group 4 (testosterone: 5 mg/kg/day). At the end of the study (35 days), serum level of thyroxin, body weight, weight of testis, and prostate were determined.

RESULTS

The data showed that the body weight increased in castrated (P = 0.04) and decreased in testosterone (P = 0.00) groups but did not differ in finasteride (P>0.05) group. There were not any differences in the weight of testis among control, finasteride, and testosterone groups but the weight of prostate increased in testosterone group (P = 0.00) and decreased in castrated (P = 0.03) and finasteride groups (P = 0.04). In addition, the serum level of T4 (nmo/ml) decreased in the three groups: finasteride (P = 0.03), testosterone (P = 0.04), and castrated (P = 0.00).

CONCLUSION

Testosterone in both high and low levels decreased the amount of T4 with a time-dependent manner.

摘要

背景

甲状腺素（T4）作为甲状腺的主要激素，其分泌受雄激素调节。本研究旨在评估给予睾酮和非那雄胺以及去势对血清T4水平的影响，并展示这种调节对总体重、睾丸重量和前列腺重量的影响。

方法

将成年雄性大鼠（n = 32）分为4组（n = 8）：第1组（对照组）、第2组（去势组）、第3组（非那雄胺：20毫克/千克/天）和第4组（睾酮：5毫克/千克/天）。在研究结束时（35天），测定血清甲状腺素水平、体重、睾丸重量和前列腺重量。

结果

数据显示，去势组体重增加（P = 0.04），睾酮组体重下降（P = 0.00），而非那雄胺组体重无差异（P>0.05）。对照组、非那雄胺组和睾酮组的睾丸重量无差异，但睾酮组前列腺重量增加（P = 0.00），去势组（P = 0.03）和非那雄胺组（P = 0.04）前列腺重量下降。此外，非那雄胺组（P = 0.03）、睾酮组（P = 0.04）和去势组（P = 0.00）的血清T4水平（纳摩尔/毫升）均下降。

结论

高水平和低水平的睾酮均以时间依赖的方式降低T4的量。