Loftsson Thorsteinn, Hreinsdôttir Dagný
Faculty of Pharmacy, University of Iceland, Hofsvallagata 53, IS-107, Reykjavik, Iceland.
AAPS PharmSciTech. 2006 Mar;7(1):E29-E32. doi: 10.1208/pt070104. Epub 2017 Mar 8.
A modified shake-flask solubility method, where the equilibration time was shortened through heating, was used to determine the solubility of 48 different drugs and pharmaceutical excipients in pure water at room temperature. The heating process accelerates dissolution of the solid compound and frequently results in supersaturated solution. Seeding with the solid compound after heating and cooling to room temperature promotes precipitation of the solid compound in its original stable form. This modified shake-flask method generates reliable and reproducible solubility data.
一种改进的摇瓶溶解度测定方法被用于测定48种不同药物及药用辅料在室温纯水中的溶解度，该方法通过加热缩短了平衡时间。加热过程加速了固体化合物的溶解，并常常导致形成过饱和溶液。在加热并冷却至室温后加入该固体化合物晶种，可促使固体化合物以其原始稳定形式析出。这种改进的摇瓶法能产生可靠且可重复的溶解度数据。
