体外递送和多柔比星控释用于靶向骨肉瘤骨癌。

In vitro delivery and controlled release of Doxorubicin for targeting osteosarcoma bone cancer.

机构信息

Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, UPM 43400, Serdang, Malaysia.

出版信息

Molecules. 2013 Aug 30;18(9):10580-98. doi: 10.3390/molecules180910580.

Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In this research, we developed and demonstrated a bio-based calcium carbonate nanocrystals carrier that can be loaded with anticancer drug and selectively deliver it to cancer cells with high specificity by achieving the effective osteosarcoma cancer cell death without inducing specific toxicity. The results showed pH sensitivity of the controlled release characteristics of the drug at normal physiological pH 7.4 with approximately 80% released within 1,200 min but when exposed pH 4.8 the corresponding 80% was released in 50 min. This study showed that the DOX-loaded CaCO₃ nanocrystals have promising applications in delivery of anticancer drugs.

药物传递系统旨在通过在所需部位成功传递治疗剂，实现药物治疗指数并增强靶向控制药物释放的功效，具有特异性和选择性，而不会影响非患病邻近细胞或组织。在这项研究中，我们开发并展示了一种基于生物的碳酸钙纳米晶体载体，它可以负载抗癌药物，并通过实现有效的骨肉瘤癌细胞死亡而不引起特定毒性，高度特异性地将其递送到癌细胞中。结果表明，在正常生理 pH 值 7.4 下，药物的释放具有 pH 敏感性，约 80%的药物在 1200 分钟内释放，但当暴露于 pH 值 4.8 时，相应的 80%在 50 分钟内释放。本研究表明，载有 DOX 的 CaCO₃纳米晶体在抗癌药物的传递中有很好的应用前景。