Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstrasse 18, 76131, Karlsruhe, Germany; Zell- und Neurobiologie, Zoologisches Institut, Karlsruhe Institute of Technology (KIT), Haid-und-Neu-Str. 9, Karlsruhe and Institut für Funktionelle Grenzflächen (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Adv Mater. 2013 Nov 13;25(42):6123-7. doi: 10.1002/adma.201302492. Epub 2013 Sep 3.
Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.
受生物启发的聚多巴胺 (PDA) 薄膜与具有抗污性的聚 (MeOEGMA) 刷结合在一起，利用腈亚胺介导的四唑-烯环加成 (NITEC) 基光触发表面编码协议。在 PDA 表面上对防污刷进行光图案化处理，导致细胞在未照射部分形成致密层，而在刷上则不会发生附着，从而形成非常精确的细胞图案。所提出的策略为设计定制的图案化细胞界面铺平了道路。
