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基于聚磷酸酯的阳离子纳米颗粒偶然释放出完整的具有生物活性的成分，可用作新型可降解诱导型一氧化氮合酶抑制剂。

Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors.

机构信息

Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri, 63130, USA.

出版信息

Adv Mater. 2013 Oct 18;25(39):5609-14. doi: 10.1002/adma.201302842. Epub 2013 Sep 3.

DOI:10.1002/adma.201302842
PMID:23999874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4404032/
Abstract

A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.

摘要

一种可降解的聚磷酸酯（PPE）基阳离子纳米颗粒（cSCK），作为一种新型的可降解药物装置，被集成构建，它能够显著抑制诱导型一氧化氮合酶（iNOS）的转录，最终抑制一氧化氮（NO）的过度产生，而无需装载任何特定的治疗药物。该系统有望成为一种治疗急性肺损伤的抗炎药物。

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