心血管疾病的全球负担：内皮功能和动脉弹性在心血管疾病中的作用作为新型和新兴生物标志物。
The Global Burden of Cardiovascular Disease: The Role of Endothelial Function and Arterial Elasticity in Cardiovascular Disease as Novel and Emerging Biomarkers.
作者信息
Glasser Stephen P, Dudenbostel Tanja
机构信息
Division of Preventive Medicine and Department of Epidemiology, University of Alabama at Birmingham, 1717 11th Avenue South MT638, Birmingham, AL 35205, USA.
出版信息
Curr Cardiovasc Risk Rep. 2011 Apr 1;5(2):187-195. doi: 10.1007/s12170-010-0151-3.
Abstract
Some consider the measurements of arterial elasticity and flow-mediated dilation to be an indirect "biomarker" of endothelial dysfunction. As such, we describe the various uses of these techniques in the evaluation of the natural history of vascular disease. These measures are potential markers of disease, as abnormalities reflect changes in the integrity of vascular structure but occur prior to the manifestation of symptomatic cardiovascular events. In this review, the natural history of arterial elasticity is discussed, and the effects of aging and inflammation are reviewed. The role that arterial elasticity and flow-mediated dilation have in predicting future cardiovascular disease, and the effects of pharmacologic agents on these measures, is also reviewed.
摘要
一些人认为动脉弹性和血流介导的扩张测量是内皮功能障碍的间接“生物标志物”。因此，我们描述了这些技术在评估血管疾病自然史中的各种用途。这些测量是疾病的潜在标志物，因为异常反映了血管结构完整性的变化，但发生在有症状的心血管事件出现之前。在这篇综述中，讨论了动脉弹性的自然史，并回顾了衰老和炎症的影响。还综述了动脉弹性和血流介导的扩张在预测未来心血管疾病中的作用，以及药物对这些测量的影响。
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