Husmann Marc, Jacomella Vincenzo, Thalhammer Christoph, Amann-Vesti Beatrice R
1 Clinic for Angiology, University Hospital Zurich and University of Zurich, Switzerland.
Vasa. 2015 Sep;44(5):341-8. doi: 10.1024/0301-1526/a000452.
Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.
动脉僵硬度增加是由于动脉壁弹性降低所致，是心血管风险的独立预测指标。评估动脉僵硬度的金标准是颈股脉搏波速度。其他参数，如中心主动脉脉压和主动脉增强指数，是动脉僵硬度的间接替代指标，但可提供有关波反射特征的额外信息。外周动脉疾病（PAD）的特点是与收缩期高血压、动脉僵硬度增加、波反射紊乱以及取决于踝臂压力指数的预后相关。本综述总结了脉搏波传播和反射的生理学及其因衰老和动脉粥样硬化而发生的变化。我们讨论了不同的非侵入性评估技术，并强调了在PAD背景下，每位血管专科医生和初级保健医生理解动脉脉搏波分析的重要性。
