Saijo Yasuaki, Utsugi Megumi, Yoshioka Eiji, Horikawa Naoko, Sato Tetsuro, Gong Yingyan, Kishi Reiko
Department of Health Science, Asahikwa Medical College, Midorigaoka, E2-1-1-1, Asahikawa, Hokkaido 078-8510, Japan.
Nutr Metab Cardiovasc Dis. 2008 Mar;18(3):211-9. doi: 10.1016/j.numecd.2006.10.002. Epub 2007 Apr 6.
The relationships between gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether serum GGT is related to CRP and arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV).
The subjects were 3412 males and 854 females. GGT, CRP, baPWV, and conventional risk factors were evaluated. On multiple regression analysis, after adjustment for the conventional risk factors, log GGT was significantly associated with log CRP in male and female subjects (male subjects: beta=0.168, p<0.0001; female subjects: beta=0.098, p<0.05). After adjustment for the conventional risk factors, log GGT was significantly associated with PWV in male subjects (beta=0.060, p<0.0001), but in female subjects, no significant relationships were found after adjustment (beta=0.007, p=0.82).
These results suggest that GGT is independently associated with an increased level of CRP in both males and females. In addition, in males, GGT is related to an increased level of arterial stiffness.
γ-谷氨酰转移酶（GGT）、C反应蛋白（CRP）与动脉僵硬度之间的关系尚未得到充分研究。本研究旨在阐明血清GGT是否与CRP以及使用臂踝脉搏波速度（baPWV）评估的动脉僵硬度相关。
研究对象包括3412名男性和854名女性。对GGT、CRP、baPWV及传统危险因素进行了评估。多元回归分析显示，在对传统危险因素进行校正后，男性和女性受试者中log GGT均与log CRP显著相关（男性受试者：β=0.168，p<0.0001；女性受试者：β=0.098，p<0.05）。在对传统危险因素进行校正后，男性受试者中log GGT与PWV显著相关（β=0.060，p<0.0001），但在女性受试者中，校正后未发现显著相关性（β=0.007，p=0.82）。
这些结果表明，GGT在男性和女性中均与CRP水平升高独立相关。此外，在男性中，GGT与动脉僵硬度升高有关。
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