抗结剂和癫痫持续状态中的 microRNA。
Antagomirs and microRNA in status epilepticus.
机构信息
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen’s Green, Dublin 2, Ireland.
出版信息
Epilepsia. 2013 Sep;54 Suppl 6(0 6):17-9. doi: 10.1111/epi.12267.
Abstract
MicroRNAs are an important class of noncoding RNA, which function as posttranscriptional regulators of protein levels within cells. Emerging work has revealed that status epilepticus produces select changes to microRNA levels within the brain, which may impact levels of proteins involved in neuronal structure and excitability, gliosis, inflammation, and apoptosis. Animal studies show that targeting microRNAs using locked nucleic acid-modified oligonucleotides ("antagomirs") can have potent effects on status epilepticus, seizure-induced neuronal death, and the later emergence of recurrent spontaneous seizures. Accordingly, microRNA-based therapeutics may have potential as a future treatment of status epilepticus.
摘要
微小 RNA 是一类重要的非编码 RNA，作为细胞内蛋白质水平的转录后调控因子发挥作用。新出现的研究表明，癫痫持续状态会导致大脑中特定的微小 RNA 水平发生变化，这可能会影响涉及神经元结构和兴奋性、神经胶质增生、炎症和细胞凋亡的蛋白质水平。动物研究表明，使用锁核酸修饰的寡核苷酸（“反义寡核苷酸”）靶向微小 RNA 可以对癫痫持续状态、癫痫诱导的神经元死亡以及随后出现的复发性自发性癫痫产生强烈的影响。因此，基于微小 RNA 的治疗方法可能有希望成为癫痫持续状态的未来治疗方法。
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