Dybendal T, Vik H, Elsayed S
Allergy Research Group, Laboratory of Clinical Biochemistry, University Hospital, Bergen, Norway.
Ann Occup Hyg. 1990 Apr;34(2):215-29. doi: 10.1093/annhyg/34.2.215.
The effects of detergents on antigens and allergens of birch and timothy grass pollen extracts, codfish, hen egg-white, cat dander and house dust mite were investigated by crossed immunoelectrophoresis (CIE), crossed radio-immunoelectrophoresis (CRIE), radio-allergosorbent test (RAST) inhibition and quantitative precipitation test using laser nephelometry. Nine household cleaning solutions and five chemical detergents were tested. Higher concentrations than recommended for regular cleaning purposes were used as no influence on the antigenic and allergenic activities could be detected using the usual concentrations. Soft soap, guanidine hydrochloride and sodium lauryl sulphate induced most modifications of the antigens and allergens tested. None of the detergents totally destroyed the antigenic and allergenic activities of the selected material, even when used in concentrations up to 10 times that recommended. The materials used for carpet cleaning would not be able to impose any denaturing effects on allergens left on carpets after cleaning.
通过交叉免疫电泳（CIE）、交叉放射免疫电泳（CRIE）、放射变应原吸附试验（RAST）抑制以及使用激光散射比浊法的定量沉淀试验，研究了洗涤剂对桦树和梯牧草花粉提取物、鳕鱼、鸡蛋白、猫皮屑和屋尘螨的抗原和变应原的影响。测试了九种家用清洁溶液和五种化学洗涤剂。使用的浓度高于常规清洁目的所推荐的浓度，因为使用常规浓度时未检测到对抗原性和变应原活性的影响。软皂、盐酸胍和十二烷基硫酸钠对所测试的抗原和变应原引起的改变最多。即使以高达推荐浓度10倍的浓度使用，也没有一种洗涤剂能完全破坏所选材料的抗原性和变应原活性。用于地毯清洁的材料在清洁后不会对留在地毯上的变应原产生任何变性作用。
