Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran; Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.
Pathol Res Pract. 2013 Nov;209(11):689-91. doi: 10.1016/j.prp.2013.07.008. Epub 2013 Aug 6.
Gastric cancer is the second most frequent cause of cancer death worldwide. In Iran, gastric cancer is the first cause of national cancer-related mortality in men and the second one in women. In mammals, the Musashi family of RNA binding proteins comprises the Musashi1 and Musashi2 proteins, encoded by the MSI1 and MSI2 genes. Mammalian Musashi contributes to the self-renewal of various types of stem cells. Furthermore, there is mounting evidence that stem cells exist in many tissues. Due to this, Msi appears to be associated with tumorigenesis. In the present study, 30 paired gastric tissue samples were examined for MSI2 gene expression by quantitative real-time RT-PCR. Our results demonstrated that the relative expression of the gene did not significantly alter between tumoral and non-tumoral tissues and different tumor types; but there was a statistical difference between the MSI2 gene expression in different tumor grades, of note between grade I and grade II.
胃癌是全球癌症死亡的第二大常见原因。在伊朗，胃癌是男性癌症相关死亡的首要原因，在女性中则是第二大原因。在哺乳动物中，RNA 结合蛋白的 Musashi 家族包括 Musashi1 和 Musashi2 蛋白，由 MSI1 和 MSI2 基因编码。哺乳动物 Musashi 有助于各种类型干细胞的自我更新。此外，越来越多的证据表明，干细胞存在于许多组织中。因此，Msi 似乎与肿瘤发生有关。在本研究中，通过定量实时 RT-PCR 检查了 30 对胃癌组织样本中 MSI2 基因的表达。我们的结果表明，基因在肿瘤组织和非肿瘤组织以及不同肿瘤类型之间的相对表达没有显著改变；但是，不同肿瘤分级的 MSI2 基因表达存在统计学差异，尤其是在 1 级和 2 级之间。
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