Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia 30322.
Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a015503. doi: 10.1101/cshperspect.a015503.
Large animal models have long served as the proving grounds for advances in transplantation, bridging the gap between inbred mouse experimentation and human clinical trials. Although a variety of species have been and continue to be used, the emergence of highly targeted biologic- and antibody-based therapies has required models to have a high degree of homology with humans. Thus, the nonhuman primate has become the model of choice in many settings. This article will provide an overview of nonhuman primate models of transplantation. Issues of primate genetics and care will be introduced, and a brief overview of technical aspects for various transplant models will be discussed. Finally, several prominent immunosuppressive and tolerance strategies used in primates will be reviewed.
大型动物模型长期以来一直是移植领域进展的试验场，填补了近交系小鼠实验和人体临床试验之间的空白。虽然已经有多种物种被使用，并将继续被使用，但高度靶向的生物和抗体治疗的出现要求模型与人具有高度的同源性。因此，非人类灵长类动物已成为许多情况下的首选模型。本文将概述移植的非人类灵长类动物模型。将介绍灵长类动物遗传学和护理方面的问题，并简要介绍各种移植模型的技术方面。最后，将回顾灵长类动物中使用的几种突出的免疫抑制和耐受策略。
