预测严重脓毒症和脓毒性休克的治疗失败：寻找圣杯。
Predicting treatment failure in severe sepsis and septic shock: looking for the Holy Grail.
作者信息
Ruiz-Rodríguez Juan, Rello Jordi
出版信息
Crit Care. 2013 Sep 4;17(5):180. doi: 10.1186/cc12877.
Abstract
Procalcitonin has been proposed as a specific biomarker of bacterial infections and has been related to the severity of sepsis. The prognostic ability of the initial concentrations of procalcitonin in sepsis is controversial. Some studies find higher initial concentrations in non-survivors but others find no differences. Prognostic assessment based on follow-up of procalcitonin levels may be better than evaluation of the initial levels of procalcitonin. The persistence of elevated procalcitonin levels is indicative of poor prognosis and is associated with mortality. Procalcitonin kinetics could be a tool for assessing the evolution of severe sepsis and sepsis shock. Procalcitonin should find its place as a biomarker for predicting treatment failure of severe sepsis and septic shock.
摘要
降钙素原已被提议作为细菌感染的特异性生物标志物，并与脓毒症的严重程度相关。脓毒症中降钙素原初始浓度的预后能力存在争议。一些研究发现非幸存者的初始浓度较高，但其他研究未发现差异。基于降钙素原水平随访的预后评估可能优于对降钙素原初始水平的评估。降钙素原水平持续升高表明预后不良，并与死亡率相关。降钙素原动力学可能是评估严重脓毒症和脓毒症休克进展的一种工具。降钙素原应作为预测严重脓毒症和脓毒症休克治疗失败的生物标志物。
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