Ariake Kyohei, Miura Masahito, Takahashi Michinaga, Ueno Tatsuya, Sato Shun, Akada Masanori, Maeda Shimpei, Fujisaka Yasuyuki, Ohto Takashi, Naito Hiroo
Department of Surgery, South Miyagi Medical Center.
Nihon Shokakibyo Gakkai Zasshi. 2013 Sep;110(9):1633-9.
A female in her 50s with a four-year history of myotonic dystrophy was admitted to our hospital with hematochezia. She was diagnosed with synchronous colonic cancer of the transverse and sigmoid colon, for which she underwent partial transverse and sigmoid colectomy, respectively. Postoperative respiratory failure resulted in prolonged stay in the intensive care unit. Her liver and renal function gradually deteriorated, and she eventually died from these sequelae on postoperative day 26. Intraoperative liver biopsy revealed cirrhosis arising from non-alcoholic steatohepatitis (NASH). Although myotonic dystrophy is believed to be a multisystem disease, its association with cirrhosis has not been reported in Japan. We therefore report this rare case of liver cirrhosis arising from NASH in a patient with myotonic dystrophy.
一名50多岁、有4年强直性肌营养不良病史的女性因便血入院。她被诊断为横结肠和乙状结肠同时性结肠癌，为此分别接受了部分横结肠和乙状结肠切除术。术后呼吸衰竭导致在重症监护病房长期住院。她的肝肾功能逐渐恶化，最终在术后第26天死于这些后遗症。术中肝脏活检显示为非酒精性脂肪性肝炎（NASH）引起的肝硬化。虽然强直性肌营养不良被认为是一种多系统疾病，但在日本尚未有其与肝硬化相关的报道。因此，我们报告了这例强直性肌营养不良患者中由NASH引起肝硬化的罕见病例。
