慢性脑脊髓静脉功能不全与多发性硬化症相关性的荟萃分析。
Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.
作者信息
Zwischenberger Brittany A, Beasley Mary M, Davenport Daniel L, Xenos Eleftherios S
机构信息
1General Surgery Residency Program, University of Kentucky, Lexington, KY, USA.
出版信息
Vasc Endovascular Surg. 2013 Nov;47(8):620-4. doi: 10.1177/1538574413503562. Epub 2013 Sep 4.
PURPOSE
To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS).
MATERIALS AND METHODS
A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls.
RESULTS
In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I (2) = 18, P = .279).
CONCLUSIONS
The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.
目的
确定慢性脑脊髓静脉功能不全（CCSVI）与多发性硬化症（MS）之间是否存在相关性。
材料与方法
对当前文献进行荟萃分析，以评估根据彩色多普勒超声标准诊断的MS患者和正常对照者中CCSVI的发生率。
结果
从2005年1月至2013年2月共鉴定出19项研究；然而，由于数据重复排除了3项研究，另外3项研究因MS组和对照组均无患者符合CCSVI标准而被排除。为提高同质性，分析中还剔除了4项离群值研究。对其余9项研究的分析表明，CCSVI与MS之间存在显著相关性（优势比1.885，P <.0001），且研究间无显著异质性（I(2)=18，P =.279）。
结论
荟萃分析表明CCSVI与MS之间存在相关性。然而，没有证据表明CCSVI在MS中起致病作用。
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