Emergency Medicine Department, National University Health System, Singapore.
Singapore Med J. 2013 Aug;54(8):e164-8. doi: 10.11622/smedj.2013162.
The Gram-negative bacilli Acinetobacter baumannii, Burkholderia cepacia, Ochrobactrum anthropi, Pseudomonas mendocina, Ralstonia spp., Serratia marcescens and Stenotrophomonas maltophilia are ubiquitous environmental organisms of low virulence, and do not usually cause illness in immunocompetent hosts. We report a case of multiple concurrent opportunistic Gram-negative bacilli causing septic arthritis in a healthy patient following trauma to the knee. Repeated operations, including arthroscopy, arthrotomy and debridement, were required before tissue cultures became negative. The patient also required an extended duration of intravenous and oral antibiotic treatment before he was discharged. Gram-negative bacillary septic arthritis is an uncommon but significant condition that requires repeated debridement and washouts in order to achieve bacterial eradication. This case report highlights the importance of an awareness of the external environment at the time of injury, as it impacts the type of organisms causing the infection, and consequently, the choice of empiric antibiotics required for successful treatment.
革兰氏阴性杆菌鲍曼不动杆菌、洋葱伯克霍尔德菌、奥尔森氏菌、门多萨假单胞菌、罗尔斯顿菌属、粘质沙雷氏菌和嗜麦芽寡养单胞菌是低毒力的普遍存在的环境生物体,通常不会在免疫功能正常的宿主中引起疾病。我们报告了一例健康患者在膝关节创伤后同时发生多种机会性革兰氏阴性杆菌引起的化脓性关节炎。在组织培养转为阴性之前,需要反复进行多次手术,包括关节镜检查、关节切开术和清创术。患者还需要长时间的静脉内和口服抗生素治疗才能出院。革兰氏阴性杆菌化脓性关节炎是一种不常见但很严重的疾病,需要反复清创和冲洗以实现细菌根除。本病例报告强调了在受伤时对外部环境的认识的重要性,因为它会影响引起感染的病原体类型,进而影响成功治疗所需的经验性抗生素选择。