Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA Veterans Affairs Medical Center, Oklahoma City, OK, USA
Department of Biostatistics and Epidemiology, University of Oklahoma HSC, Oklahoma City, OK, USA.
Angiology. 2014 Sep;65(8):683-90. doi: 10.1177/0003319713501376. Epub 2013 Sep 3.
We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 130 patients with peripheral artery disease (PAD) and a control group of 36 patients with high burden of comorbid conditions and cardiovascular risk factors. Second, we compared circulating inflammatory, antioxidant capacity, and vascular biomarkers between the groups. The groups were not significantly different (P > .05) on apoptosis, hydrogen peroxide, hydroxyl radical antioxidant capacity, and nuclear factor κ-light-chain enhancer of activated B cells. Circulating tumor necrosis factor α (TNF-α; P = .016) and interleukin 8 (IL-8; P = .006) were higher in the PAD group, whereas vascular endothelial growth factor A (VEGF-A; P = .023) was lower. The PAD does not impair the endothelium beyond that which already occurs from comorbid conditions and cardiovascular risk factors in patients with claudication. However, patients with PAD have lower circulating VEGF-A than the control group and higher circulating inflammatory parameters of TNF-α and IL-8.
我们比较了 130 例外周动脉疾病 (PAD) 患者的血清和 36 例合并症和心血管危险因素负担较高的对照组培养的内皮细胞的凋亡、细胞氧化应激和炎症。其次，我们比较了两组之间的循环炎症、抗氧化能力和血管生物标志物。两组在凋亡、过氧化氢、羟自由基抗氧化能力和核因子κB 轻链增强子的活化 B 细胞方面无显著差异（P＞.05）。循环肿瘤坏死因子α（TNF-α；P=.016）和白细胞介素 8（IL-8；P=.006）在 PAD 组中较高，而血管内皮生长因子 A（VEGF-A；P=.023）较低。与跛行患者的合并症和心血管危险因素已经导致的内皮损伤相比，PAD 并没有进一步损害内皮。然而，与对照组相比，PAD 患者的循环 VEGF-A 水平较低，而循环炎症参数 TNF-α和 IL-8 水平较高。
