Instituto de Medicina Tropical Alexander von Humbolt, Lima, Peru.
Am J Trop Med Hyg. 2013 Sep;89(3):434-44. doi: 10.4269/ajtmh.13-0264.
Abstract. Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus-infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus-infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.
摘要。现行法规规定每 10 年接种一次黄热病（YF）加强针。我们对黄热病疫苗在疾病流行地区居民和旅行者中的保护效力和免疫持续时间进行了系统评价，以评估在这两种情况下以及在某些特定人群（感染人类免疫缺陷病毒者、婴儿、儿童、孕妇和严重营养不良者）中是否需要加强针。共纳入 36 项研究和 22 份报告。我们确定了 12 项关于免疫原性的研究、8 项关于免疫持久性的研究、8 项关于婴儿和儿童疫苗反应的研究、7 项关于感染人类免疫缺陷病毒者的研究、2 项关于孕妇的研究和 1 项关于严重营养不良儿童的研究。基于现有数据，YF 疫苗单剂具有高度免疫原性，并能对 YF 提供持续终身的保护作用。因此，不需要接种 YF 疫苗加强针。详细说明了某些特定人群的特殊考虑因素。
