在JTB-X上衍生化酸和胺的拆分：一种新型尿素键合手性固定相。
Resolution of derivatized acids and amines on JTB-X: a new urea bonded chiral stationary phase.
作者信息
Kakodkar S V, Zief M
机构信息
J.T. Baker Inc., Phillipsburg, New Jersey 08865.
出版信息
Chirality. 1990;2(2):124-7. doi: 10.1002/chir.530020210.
PMID:2400638
Abstract
A new urea-bonded chiral stationary phase has been developed in our laboratory. This bonded phase has been shown to resolve N-terminal substituted amino acids and the carboxyl derivatized anti-inflammatory drugs. Typical alpha-value for dinitrobenzoyl phenylglycine was 1.7. Values for derivatized ibuprofen, naproxen, and fenoprofen were 2, 1.84, and 1.6, respectively. Further application of these studies to biologically active compounds such as peptides and drugs is in progress.
摘要
我们实验室已开发出一种新型的尿素键合手性固定相。这种键合相已被证明能够拆分N-末端取代氨基酸和羧基衍生化的抗炎药物。二硝基苯甲酰苯甘氨酸的典型α值为1.7。衍生化布洛芬、萘普生和非诺洛芬的值分别为2、1.84和1.6。这些研究在生物活性化合物如肽和药物方面的进一步应用正在进行中。
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