Resolution of derivatized acids and amines on JTB-X: a new urea bonded chiral stationary phase.

A new urea-bonded chiral stationary phase has been developed in our laboratory. This bonded phase has been shown to resolve N-terminal substituted amino acids and the carboxyl derivatized anti-inflammatory drugs. Typical alpha-value for dinitrobenzoyl phenylglycine was 1.7. Values for derivatized ibuprofen, naproxen, and fenoprofen were 2, 1.84, and 1.6, respectively. Further application of these studies to biologically active compounds such as peptides and drugs is in progress.