Sevelda P, Denison U, Schemper M, Spona J, Vavra N, Salzer H
First Department of Gynecology and Obstetrics, University of Vienna, Austria.
Br J Obstet Gynaecol. 1990 Aug;97(8):706-12. doi: 10.1111/j.1471-0528.1990.tb16243.x.
Levels of oestrogen receptor (ER) and progesterone receptor (PgR) in ovarian cancer tissue were examined with regard to their prognostic importance for survival in 179 patients with primary epithelial ovarian cancer stage III or IV in relation to: FIGO-stage, histological type, histological grade, age, ascites, and postoperative residual tumour. Hormone receptor content was determined with the DCC-method, receptor values higher than 9 fmol/mg protein were considered positive. Response to postoperative chemotherapy was significantly correlated with PgR content (80% responders in the group with PgR positive tumours and only 61% responders in the group with PgR negative tumours). A Cox proportional hazards regression model identified histological grade, residual tumour, age and PgR content as independent prognostic factors for survival in advanced epithelial ovarian carcinoma. PgR content had particularly significant prognostic relevance for patients with postoperative residual tumour mass less than or equal to 2 cm in diameter. Within this group of patients, those who are PgR positive have a 2-years survival probability of 83% compared with only 51% in the PgR-negative group.
对179例原发性III期或IV期上皮性卵巢癌患者的卵巢癌组织中的雌激素受体（ER）和孕激素受体（PgR）水平进行了检测，以评估它们对生存的预后重要性，评估指标包括：国际妇产科联盟（FIGO）分期、组织学类型、组织学分级、年龄、腹水以及术后残留肿瘤。采用葡聚糖包被活性炭法（DCC法）测定激素受体含量，受体值高于9 fmol/mg蛋白质被视为阳性。术后化疗反应与PgR含量显著相关（PgR阳性肿瘤组的反应率为80%，而PgR阴性肿瘤组的反应率仅为61%）。Cox比例风险回归模型确定组织学分级、残留肿瘤、年龄和PgR含量为晚期上皮性卵巢癌生存的独立预后因素。对于术后残留肿瘤直径小于或等于2 cm的患者，PgR含量具有特别显著的预后相关性。在这组患者中，PgR阳性者的2年生存概率为83%，而PgR阴性组仅为51%。
