Scottish Bowel Screening Research Unit, University of Dundee, Dundee, Scotland.
J Med Screen. 2013 Jun;20(2):80-5. doi: 10.1177/0969141313497197. Epub 2013 Jul 18.
To investigate the characteristics of participants screened for bowel cancer using a faecal immunochemical test for haemoglobin (FIT).
Scottish Bowel Screening Programme.
65909 men and women in two NHS Boards, aged 50 to 74, were invited to participate in an evaluation of FIT as a first-line test. Uptake was calculated by sex, age in quintiles, and deprivation in quintiles, and compared with a group who had completed a guaiac faecal occult blood test (gFOBT) and for whom details of sex, age and deprivation were well documented.
FIT kits from 38672 participants were tested. The overall uptake of 58.7% was significantly higher than the 53.9% for gFOBT (p < 0.0001). Uptakes in the two NHS Boards were 57.6% and 54.4% for men and 63.2% and 59.1% for women, higher than the 49.5% and 58.1% completing gFOBT. Uptake was higher for FIT than gFOBT in all age and deprivation quintiles for both men and women in both NHS Boards. The difference in uptake fell with age for men but rose for women; the increase in uptake was greater for men than women. Uptake fell as deprivation decreased for both sexes, and was similar in both NHS Boards.
Use of FIT increases uptake over gFOBT, and the greatest increases are seen in men, younger participants, and more deprived individuals, groups for which an increase in uptake is likely to be beneficial. The results support a move to FIT as a first-line screening test for those countries still using gFOBT.
调查使用粪便血红蛋白免疫化学检测（FIT）筛查肠癌的参与者的特点。
苏格兰肠癌筛查计划。
在两个国民保健署（NHS）辖区内，邀请了 65909 名年龄在 50 至 74 岁的男性和女性参加 FIT 作为一线检测的评估。通过性别、五分位年龄和五分位贫困率计算参与率，并与一组已完成愈创木脂粪便潜血试验（gFOBT）且性别、年龄和贫困率详细资料记录良好的人群进行比较。
共检测了 38672 名参与者的 FIT 试剂盒。总体参与率为 58.7%，明显高于 gFOBT 的 53.9%（p<0.0001）。两个 NHS 辖区的男性参与率分别为 57.6%和 54.4%，女性为 63.2%和 59.1%，高于完成 gFOBT 的 49.5%和 58.1%。在两个 NHS 辖区内，男性和女性在所有年龄和贫困五分位中，FIT 的参与率均高于 gFOBT。对于男性，随着年龄的增长，FIT 的参与率高于 gFOBT，但对于女性则相反；男性的参与率上升幅度大于女性。对于男性和女性，参与率随着贫困程度的降低而降低，且在两个 NHS 辖区内相似。
使用 FIT 可提高 gFOBT 的参与率，对于男性、年轻参与者和贫困程度较高的人群，参与率的增加幅度最大，这可能对这些人群有益。这些结果支持将 FIT 作为那些仍在使用 gFOBT 的国家的一线筛查检测方法。
