Eyzaguirre C, Hayashida Y, Monti-Bloch L
Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108.
Brain Res. 1990 Jul 30;524(1):164-70. doi: 10.1016/0006-8993(90)90508-9.
Trophic influences of the carotid nerve (CN) on carotid body (CB) glomus cells were studied by comparing the membrane potential (Em), input resistance (Ro) and voltage noise (Erms) of normal and 3-31-day denervated cells had more negative Ems. Higher Ros were recorded at 3 and 6 days. Erms sharply increased at 3 days, returned to normal at 6-15 days and was below normal at 31 days. A transmitter (ACh) and NaCN, producing histotoxic anoxia, were used for stimulation. These substances either depolarized or hyperpolarized innervated cells and increased or decreased voltage noise. Denervation selectively changed these patterns but only for a short time. ACh preferentially depolarized the cells, only at 3 days, whereas its effects on noise did not change. The Em responses to NaCN remained unaltered although at 3-6 days noise increases were smaller and depressions exaggerated. Possible reasons for these effects are discussed.
通过比较正常和去神经支配3 - 31天的颈动脉体（CB）球细胞的膜电位（Em）、输入电阻（Ro）和电压噪声（Erms），研究了颈动脉神经（CN）对CB球细胞的营养性影响。去神经支配的细胞具有更负的Em。在第3天和第6天记录到较高的Ro。Erms在第3天急剧增加，在第6 - 15天恢复正常，在第31天低于正常水平。使用一种递质（乙酰胆碱）和产生组织中毒性缺氧的氰化钠进行刺激。这些物质使有神经支配的细胞去极化或超极化，并增加或降低电压噪声。去神经支配选择性地改变了这些模式，但仅持续较短时间。乙酰胆碱仅在第3天优先使细胞去极化，而其对噪声的影响没有变化。尽管在第3 - 6天噪声增加较小且抑制作用增强，但对氰化钠的Em反应保持不变。讨论了这些效应的可能原因。
