Eyzaguirre C, Monti-Bloch L, Hayashida Y
Brain Res. 1983 Nov 21;279(1-2):282-5. doi: 10.1016/0006-8993(83)90193-2.
Cat carotid bodies were denervated for 3-31 days by sectioning the carotid nerve. The normal response of glomus cells to cooling by about 6 degrees C, namely, membrane depolarization and reduced input resistance (Ro) was altered. At 3 days, cooling induced normal depolarization although Ro decreased more markedly. At 7 days, cooling depolarized 53% of the cells which was accompanied by variable Ro changes. Forty-seven percent of the cells were hyperpolarized and their Ro increased. At 16 days, a fall in temperature depolarized 25% of the cells which showed variable changes in Ro, whereas the rest showed hyperpolarization and increased Ro. At 31 days, cooling weakly depolarized 64% of the cells together with a small reduction in Ro whereas 28% showed some hyperpolarization and larger Ro. It is concluded that sensory denervation alters the membrane of glomus cells, the preneuronal component of the receptor complex.
通过切断颈动脉神经，对猫的颈动脉体进行3 - 31天的去神经支配。球细胞对大约6摄氏度降温的正常反应，即膜去极化和输入电阻（Ro）降低，发生了改变。在3天时，降温诱导正常去极化，尽管Ro下降更为明显。在7天时，降温使53%的细胞去极化，同时Ro发生不同变化。47%的细胞发生超极化，其Ro增加。在16天时，温度下降使25%的细胞去极化，Ro变化不定，而其余细胞表现为超极化和Ro增加。在31天时，降温使64%的细胞轻度去极化，Ro略有降低，而28%的细胞表现出一定程度的超极化和Ro增大。结论是感觉去神经支配改变了球细胞的膜，即受体复合体的神经前成分。
