炎症性肠病中的肠道微生物群
Gut microbiota in inflammatory bowel disease.
作者信息
Shim Jung Ok
机构信息
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
出版信息
Pediatr Gastroenterol Hepatol Nutr. 2013 Mar;16(1):17-21. doi: 10.5223/pghn.2013.16.1.17. Epub 2013 Mar 31.
Abstract
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiota in the pathogenesis of pediatric IBD.
摘要
肠道黏膜屏障在维持微妙的免疫稳态中发挥着重要作用。炎症性肠病（IBD）的发病机制被认为涉及黏膜免疫缺陷以及遗传易感性。最近的观点表明，IBD患者对肠道微生物群的成分存在过度反应。在IBD患者中观察到了一种“生态失调”状态，即肠道微生物组成发生改变。在本文中，作者回顾了IBD中肠道微生物群的最新研究，特别是肠道微生物群在儿童IBD发病机制中的重要性。
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