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本文引用的文献

1
Validation of new allele-specific real-time PCR system for thiopurine methyltransferase genotyping in Korean population.验证新的用于韩国人群巯基嘌呤甲基转移酶基因分型的等位基因特异性实时 PCR 系统。
Biomed Res Int. 2013;2013:305704. doi: 10.1155/2013/305704. Epub 2013 Feb 28.
2
Thiopurine methyltransferase gene polymorphisms and activity in Chinese patients with inflammatory bowel disease treated with azathioprine.硫嘌呤甲基转移酶基因多态性及其在中国炎症性肠病患者接受硫唑嘌呤治疗中的活性。
Chin Med J (Engl). 2012 Oct;125(20):3665-70.
3
Lower doses of 6-mercaptopurine/azathioprine bring enough clinical efficacy and therapeutic concentration of erythrocyte 6-mercaptopurine metabolite in Japanese IBD patients.较低剂量的6-巯基嘌呤/硫唑嘌呤可在日本炎症性肠病患者中带来足够的临床疗效和红细胞6-巯基嘌呤代谢物的治疗浓度。
J Crohns Colitis. 2008 Dec;2(4):315-21. doi: 10.1016/j.crohns.2008.05.002. Epub 2008 Jul 3.
4
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management.第二届欧洲克罗恩病诊断与管理循证共识：当前管理
J Crohns Colitis. 2010 Feb;4(1):28-62. doi: 10.1016/j.crohns.2009.12.002. Epub 2010 Jan 15.
5
A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease.炎症性肠病患者发生肝脾 T 细胞淋巴瘤的相关因素的系统评价。
Clin Gastroenterol Hepatol. 2011 Jan;9(1):36-41.e1. doi: 10.1016/j.cgh.2010.09.016. Epub 2010 Oct 1.
6
Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.监测日本炎症性肠病儿童和青少年的6-硫鸟嘌呤核苷酸浓度。
J Gastroenterol Hepatol. 2010 Oct;25(10):1626-30. doi: 10.1111/j.1440-1746.2010.06364.x.
7
Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.硫嘌呤类药物治疗药物监测在炎症性肠病控制不佳患者中的临床应用
Inflamm Bowel Dis. 2011 Jun;17(6):1301-7. doi: 10.1002/ibd.21458. Epub 2010 Sep 1.
8
Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.巯嘌呤甲基转移酶基因型和活性对韩国炎症性肠病患者巯嘌呤诱导的白细胞减少症的影响：一项回顾性队列研究。
J Clin Gastroenterol. 2010 Nov-Dec;44(10):e242-8. doi: 10.1097/MCG.0b013e3181d6baf5.
9
Pharmacogenetics of thiopurines in inflammatory bowel disease.硫嘌呤类药物在炎症性肠病中的药物遗传学。
Curr Pharm Des. 2010;16(2):145-54. doi: 10.2174/138161210790112773.
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Risk of cancer in inflammatory bowel disease treated with azathioprine: a UK population-based case-control study.炎症性肠病患者使用硫唑嘌呤治疗后的癌症风险：一项基于英国人群的病例对照研究。
Am J Gastroenterol. 2010 Jul;105(7):1604-9. doi: 10.1038/ajg.2009.745. Epub 2010 Jan 26.

硫唑嘌呤治疗炎症性肠病的监测与安全性

Monitoring and safety of azathioprine therapy in inflammatory bowel disease.

作者信息

Kim Mi Jin, Choe Yon Ho

机构信息

Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

出版信息

Pediatr Gastroenterol Hepatol Nutr. 2013 Jun;16(2):65-70. doi: 10.5223/pghn.2013.16.2.65. Epub 2013 Jun 30.

DOI:10.5223/pghn.2013.16.2.65
PMID:24010109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3760698/
Abstract

Azathioprine is the most common drug used to maintain clinical remission in inflammatory bowel disease. This drug is also important as a steroid-sparing agent in steroid-dependent and chronically active inflammatory bowel disease. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine. The dose of azathioprine has to be reduced or the therapy has to be discontinued frequently because of drug-induced toxicity. In this review, we discuss monitoring of thiopurines, adverse events, malignant complications and how to use azathioprine safely and usefully.

摘要

硫唑嘌呤是用于维持炎症性肠病临床缓解的最常用药物。作为一种在依赖类固醇和慢性活动性炎症性肠病中节省类固醇的药物，该药也很重要。然而，关于硫唑嘌呤的最佳治疗方案仍存在许多问题。由于药物诱导的毒性，硫唑嘌呤的剂量必须减少或治疗必须经常中断。在本综述中，我们讨论了硫嘌呤类药物的监测、不良事件、恶性并发症以及如何安全有效地使用硫唑嘌呤。