磁共振成像在早期阿尔茨海默病诊断中的应用。

Magnetic resonance imaging for diagnosis of early Alzheimer's disease.

机构信息

UMR-S975, université Pierre-et-Marie-Curie-Paris-6, centre de recherche de l'institut du cerveau et de la moelle épinière, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U975, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; CNRS, UMR 7225, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; ICM, institut du cerveau et de la moelle épinière, hôpital de la Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France; INRIA, centre Paris-Rocquencourt, domaine de Voluceau-Rocquencourt, BP 105, 78153 Le Chesnay, France.

出版信息

Rev Neurol (Paris). 2013 Oct;169(10):724-8. doi: 10.1016/j.neurol.2013.07.013. Epub 2013 Sep 4.

DOI:10.1016/j.neurol.2013.07.013

PMID:24011982

Abstract

A major challenge for neuroimaging is to contribute to the early diagnosis of Alzheimer's disease (AD). In particular, magnetic resonance imaging (MRI) allows detecting different types of structural and functional abnormalities at an early stage of the disease. Anatomical MRI is the most widely used technique and provides local and global measures of atrophy. The recent diagnostic criteria of "mild cognitive impairment due to AD" include hippocampal atrophy, which is considered a marker of neuronal injury. Advanced image analysis techniques generate automatic and reproducible measures both in the hippocampus and throughout the whole brain. Recent modalities such as diffusion-tensor imaging and resting-state functional MRI provide additional measures that could contribute to the early diagnosis but require further validation.

摘要

神经影像学面临的一个主要挑战是为阿尔茨海默病（AD）的早期诊断做出贡献。特别是，磁共振成像（MRI）可以在疾病的早期发现不同类型的结构和功能异常。解剖 MRI 是最广泛使用的技术，提供了局部和全局萎缩的测量。最近的“AD 所致轻度认知障碍”的诊断标准包括海马体萎缩，海马体萎缩被认为是神经元损伤的标志物。先进的图像分析技术可以在海马体和整个大脑中生成自动和可重复的测量结果。最近的模态，如扩散张量成像和静息状态功能 MRI 提供了额外的测量指标，这可能有助于早期诊断，但需要进一步验证。