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1
And then there were none: no need for pluripotency factors to induce reprogramming.而后无他：重编程无需多能性因子。
Cell Stem Cell. 2013 Sep 5;13(3):261-2. doi: 10.1016/j.stem.2013.08.004.
2
Reprogramming of human fibroblasts to pluripotency with lineage specifiers.人成纤维细胞重编程为多能性细胞与谱系特异性蛋白。
Cell Stem Cell. 2013 Sep 5;13(3):341-50. doi: 10.1016/j.stem.2013.06.019. Epub 2013 Jul 18.
3
A chemical logic for reprogramming to pluripotency.化学逻辑用于重编程为多能性。
Cell Res. 2013 Dec;23(12):1337-8. doi: 10.1038/cr.2013.119. Epub 2013 Aug 27.
4
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.小分子化合物诱导的小鼠体细胞多能干细胞。
Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18.
5
Induction of pluripotency in mouse somatic cells with lineage specifiers.用谱系特异性蛋白诱导小鼠体细胞多能性。
Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001.
6
Reprogramming the cardiac field.重编程心脏场。
Circ Res. 2014 Jan 31;114(3):409-11. doi: 10.1161/CIRCRESAHA.113.302946.
7
Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts.简要报告：联合化学处理可实现 Oct4 诱导的小鼠胚胎成纤维细胞重编程。
Stem Cells. 2011 Mar;29(3):549-53. doi: 10.1002/stem.594.
8
Identification of a small molecule that turns ON the pluripotency gene circuitry in human fibroblasts.一种能开启人类成纤维细胞中多能性基因回路的小分子的鉴定。
ACS Chem Biol. 2014 Dec 19;9(12):2729-36. doi: 10.1021/cb500724t. Epub 2014 Nov 4.
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Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition.破坏 OCT4 的泛素化会增加 OCT4 蛋白的稳定性，并促进 ASH2L-B 介导的 H3K4 甲基化，从而促进多能性获得。
Stem Cell Reports. 2018 Oct 9;11(4):973-987. doi: 10.1016/j.stemcr.2018.09.001. Epub 2018 Sep 27.
10
NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction.NKX3-1 对于诱导多能干细胞重编程是必需的，并且可以在小鼠和人诱导多能干细胞的诱导中替代 OCT4。
Nat Cell Biol. 2018 Aug;20(8):900-908. doi: 10.1038/s41556-018-0136-x. Epub 2018 Jul 16.

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1
Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells.核因子I-C通过牙上皮干细胞中的上皮-间充质相互作用调节各种矿化组织中干细胞的干性基因和增殖。
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2
"Betwixt Mine Eye and Heart a League Is Took": The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy.“在我的眼与心之间有一个联盟被建立”：基于诱导多能干细胞的肌营养不良相关心肌病模型的进展。
Int J Mol Sci. 2020 Sep 23;21(19):6997. doi: 10.3390/ijms21196997.
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Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells.永葆青春：利用诱导多能干细胞建立非缺血性心肌病模型的开创性方法。
Stem Cells Int. 2016;2016:4287158. doi: 10.1155/2016/4287158. Epub 2016 Mar 24.
4
DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist.诱导多能性中的DLK1-DIO3印记簇：迷雾中的图景
Cell Mol Life Sci. 2014 Nov;71(22):4421-30. doi: 10.1007/s00018-014-1698-9. Epub 2014 Aug 7.
5
Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis.由miR19a/b-PTEN轴调控的人成纤维细胞重编程为多能干细胞。
PLoS One. 2014 Apr 16;9(4):e95213. doi: 10.1371/journal.pone.0095213. eCollection 2014.
6
Epigenetic regulation of open chromatin in pluripotent stem cells.多能干细胞中开放染色质的表观遗传调控。
Transl Res. 2015 Jan;165(1):18-27. doi: 10.1016/j.trsl.2014.03.004. Epub 2014 Mar 13.

本文引用的文献

1
Reprogramming of human fibroblasts to pluripotency with lineage specifiers.人成纤维细胞重编程为多能性细胞与谱系特异性蛋白。
Cell Stem Cell. 2013 Sep 5;13(3):341-50. doi: 10.1016/j.stem.2013.06.019. Epub 2013 Jul 18.
2
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.小分子化合物诱导的小鼠体细胞多能干细胞。
Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18.
3
Induction of pluripotency in mouse somatic cells with lineage specifiers.用谱系特异性蛋白诱导小鼠体细胞多能性。
Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001.
4
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells.在人类胚胎干细胞中，NANOG、OCT4 和 SOX2 具有不同的谱系特化作用。
Cell Stem Cell. 2012 Apr 6;10(4):440-54. doi: 10.1016/j.stem.2012.02.016.
5
Pluripotency factors in embryonic stem cells regulate differentiation into germ layers.胚胎干细胞中的多能性因子调节向胚层的分化。
Cell. 2011 Jun 10;145(6):875-89. doi: 10.1016/j.cell.2011.05.017.
6
A precarious balance: pluripotency factors as lineage specifiers.岌岌可危的平衡：多能性因子作为谱系特化因子。
Cell Stem Cell. 2011 Apr 8;8(4):363-9. doi: 10.1016/j.stem.2011.03.013.
7
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.通过特定因子从小鼠胚胎和成体成纤维细胞培养物中诱导多能干细胞。
Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10.
8
Long-term proliferation of mouse primordial germ cells in culture.小鼠原始生殖细胞在培养中的长期增殖。
Nature. 1992 Oct 8;359(6395):550-1. doi: 10.1038/359550a0.
9
Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture.从培养的小鼠原始生殖细胞中衍生多能胚胎干细胞。
Cell. 1992 Sep 4;70(5):841-7. doi: 10.1016/0092-8674(92)90317-6.

而后无他：重编程无需多能性因子。

And then there were none: no need for pluripotency factors to induce reprogramming.

机构信息

Stem Cell Program in the Institute for Cell Engineering and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Cell Stem Cell. 2013 Sep 5;13(3):261-2. doi: 10.1016/j.stem.2013.08.004.

DOI:10.1016/j.stem.2013.08.004
PMID:24012365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4659384/
Abstract

While most factors used as reprogramming transgenes can be replaced by other means, Oct4 has remained essential until now. Three recent papers have now broken this barrier through the use of opposing lineage specifying transgenes and chemical modulation, thus signifying a milestone in advancing our understanding of pluripotency induction.

摘要

虽然大多数作为重编程转基因的因素可以通过其他方法替代，但直到现在，Oct4 仍然是必不可少的。最近的三篇论文通过使用相反的谱系指定转基因和化学调节打破了这一障碍，从而标志着在推进我们对多能性诱导的理解方面迈出了重要的一步。