1] Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA [3] Broad Institute, Boston, MA 02115, USA [4] Harvard Stem Cell Institute, Boston, MA 02115, USA.
Cell Res. 2013 Dec;23(12):1337-8. doi: 10.1038/cr.2013.119. Epub 2013 Aug 27.
Pluripotency can be experimentally induced from somatic cells by nuclear transfer, fusion with embryonic stem cells, or ectopic transcription factor induction, but attempts to recapitulate this process by chemical means alone have previously failed. In a recent paper published in Science, Hou et al. pursue a rational, albeit laborious approach to identify cocktails of small molecules whose treatment restores pluripotency in adult somatic cells.
多能性可以通过核移植、与胚胎干细胞融合或异位转录因子诱导从体细胞中实验诱导，但以前单独通过化学手段来重现这一过程的尝试都失败了。在最近发表在《科学》杂志上的一篇论文中，侯等人采用一种合理的方法，尽管很繁琐，来鉴定小分子鸡尾酒的混合物，其处理可以恢复成年体细胞的多能性。
