Divine B J
Texaco Inc., Houston, TX 77251.
Environ Health Perspect. 1990 Jun;86:119-28. doi: 10.1289/ehp.9086119.
This is a cohort study of 2582 male workers employed at least 6 months between 1943 and 1979 at a 1,3-butadiene manufacturing facility. An earlier report on mortality through 1979 found a statistically significant deficit for all causes of death and lower than expected mortality for most of the leading causes of death. However, there was a statistically significant excess of deaths from lymphosarcoma. This report is a preliminary update of cohort information through 1985 and also a reanalysis of mortality. The all-causes standardized mortality ratio is 84 and that for all cancers is 80. These are statistically significant deficits; significant deficits were also seen for all cancer of the digestive system and all external causes of death. One additional death from lymphosarcoma was observed during the extended follow-up period giving a statistically significant standardized mortality ratio (SMR) of 229. The increase was concentrated in those employed less than 10 years and in those first employed before 1946. No increase was seen overall for leukemia (SMR = 102).
这是一项队列研究，研究对象为1943年至1979年期间在一家1,3 - 丁二烯制造工厂工作至少6个月的2582名男性工人。一份关于截至1979年死亡率的早期报告发现，所有死因的死亡率在统计学上有显著不足，且大多数主要死因的死亡率低于预期。然而，淋巴肉瘤导致的死亡在统计学上有显著超额。本报告是截至1985年队列信息的初步更新，也是对死亡率的重新分析。全死因标准化死亡率为84，所有癌症的标准化死亡率为80。这些都是统计学上的显著不足；消化系统所有癌症和所有外部死因的死亡率也有显著不足。在延长随访期内又观察到1例淋巴肉瘤死亡病例，标准化死亡率（SMR）为229，具有统计学显著性。这种增加集中在工作年限不足10年的人群以及1946年前首次就业的人群中。白血病总体上没有增加（SMR = 102）。
